Stochastic vs. deterministic uptake of dodecanedioic acid by isolated rat livers

被引:0
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作者
Susanne Ditlevsen
Andrea de Gaetano
机构
[1] University of Copenhagen,Department of Biostatistics, Panum Institute
[2] Università Cattolica del Sacro Cuore,CNR IASI, Laboratorio di Biomatematica
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关键词
Mathematical Biology; Deterministic Model; Stochastic Differential Equation; Dynamic Noise; Approximate Maximum Likelihood;
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摘要
Deterministic and stochastic differential equations models of the uptake of dodecanedioic acid (C12) are fitted to experimental data obtained on nine isolated, perfused rat livers. 11500 μg of C12 were injected as a bolus into the perfusing liver solution. The concentrations of C12 in perfusate samples taken over 2 h from the beginning of the experiments were analyzed by High Performance Liquid Chromatography (HPLC).
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页码:547 / 561
页数:14
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