Potential targets for the development of new antifungal drugs

被引：0
作者：
Hao Su
Li Han
Xueshi Huang
机构：
[1] Northeastern University,Institute of Microbial Pharmaceuticals, College of Life and Health Sciences
来源：
The Journal of Antibiotics | 2018年 / 71卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In recent years, incidences of invasive fungal infections have greatly increased, especially in immunosuppressed patients, but most today's antifungal drugs are not completely effective due to the development of drug resistance, as well as potential toxicity and adverse effects. Consequently, it is imperative to search for novel antifungal agents to combat fungal infections. This review will discuss the advances in the traditional antifungal therapy, and present an overview of novel strategies for the treatment of fungal infections. The papers presented here highlight new targets that could be exploited for development of new antifungal agents.
引用
收藏
页码：978 / 991
页数：13
相关论文
共 241 条
  • [41] Brown AJP(2015) methionine synthase: expression analysis and requirement for virulence Lett Appl Microbiol 60 20-28
  • [42] Gow NAR(2004)Simultaneous in vitro assay of the first four enzymes in the fungal aspartate pathway identifies a new class of aspartate kinase inhibitor Eukaryot Cell 3 1287-37
  • [43] Kathiravan MK(2017)Metabolism of sulfur amino acids in J Microbiol Immunol Infect 50 863-75
  • [44] Wiederhold NP(2003)Role of homoserine transacetylase as a new target for antifungal agents Chem Biol 10 989-37
  • [45] Espinel-Ingroff A(2000)β-Lactone natural products and derivatives inactivate homoserine transacetylase, a target for antimicrobial agents Yeast 16 1205-67
  • [46] McCarthy MW(2010)Disrupting the methionine biosynthetic pathway in Eukaryot Cell 9 717-39
  • [47] Kontoyiannis DP(2010): characterization of the Eukaryot Cell 9 729-58
  • [48] Cornely OA(2008) gene as counter-selectable marker Microbiology 154 2767-24
  • [49] Perfect JR(2010)ATP sulfurylase is essential for the utilization of sulfamate as a sulfur source in the yeast Chem Biol 17 28-80
  • [50] Walsh TJ(2013) (syn. Bioorg Med Chem 21 4958-8
12345678910