Metabolic activity of cells in brain cortex after alcohol intoxication and correction of changes with Dolivin

被引：0
|
作者：
D. P. Museridze
T. V. Sanikidze
I. K. Svanidze
机构：
[1] Georgian Academy of Sciences,I. S. Beritashvili Institute of Physiology
[2] Georgian State Medical University,Institute of Clinical and Experimental Medicine
来源：
Bulletin of Experimental Biology and Medicine | 2006年 / 142卷
关键词：
brain cortex; ethanol; Dolivin; peroxidation; radicals;
D O I：
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学科分类号：
摘要：
Metabolic processes in the brain cortex of albino rats with prenatal and postnatal alcohol intoxication were studied by the method of electron paramagnetic resonance. Accumulation of superoxide radical-generating agents, inactivation of superoxide dismutase, and increase in nitric oxide concentration were detected. Activation of free radical processes was associated with accumulation of Mn2+ and Fe2+. The parameters of electron paramagnetic resonance returned to normal after Dolivin treatment. These changes were accompanied by a decrease in the intensity of oxidative metabolism.
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页码：283 / 285
页数：2
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