The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca2+ release channels

被引：0
|
作者：
Antony Galione
A. Mark Evans
Jianjie Ma
John Parrington
Abdelilah Arredouani
Xiaotong Cheng
Michael X. Zhu
机构：
[1] University of Oxford,Department of Pharmacology
[2] University of Edinburgh,Centre for Integrative Physiology, College of Medicine and Veterinary Medicine
[3] UMDNJ–Robert Wood Johnson Medical School,Department of Physiology and Biophysics
[4] The Ohio State University,Department of Neuroscience, Biochemistry and Center for Molecular Neurobiology
来源：
Pflügers Archiv - European Journal of Physiology | 2009年 / 458卷
关键词：
Inositol 1,4,5-trisphosphate; Pancreatic β-cell; Endothelin; Cholecystokinin; Ca; -induced Ca; release; Ion channel; Ca; mobilisation; Ca; stores; Calcium signalling; Calcium transient;
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学科分类号：
摘要：
In this review, we describe the background and implications of our recent discovery that two-pore channels (TPCs) comprise a novel class of calcium release channels gated by the intracellular messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Their localisation to the endolysosomal system highlights a new function for these organelles as targets for NAADP-mediated Ca2+ mobilisation. In addition, we describe how TPCs may also trigger further Ca2+ release by coupling to the endoplasmic reticular stores through activation of IP3 receptors and ryanodine receptors.
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页码：869 / 876
页数：7
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