Latozinemab, a novel progranulin-elevating therapy for frontotemporal dementia

被引：0
|
作者：
Michael Kurnellas
Ananya Mitra
Tina Schwabe
Robert Paul
Andrew E. Arrant
Erik D. Roberson
Michael Ward
Felix Yeh
Hua Long
Arnon Rosenthal
机构：
[1] Alector,Center for Neurodegeneration and Experimental Therapeutics, Alzheimer’s Disease Center, and Evelyn F. McKnight Brain Institute, Departments of Neurology and Neurobiology
[2] Inc.,undefined
[3] University of Alabama at Birmingham,undefined
[4] Neuron23,undefined
[5] Nine Square Therapeutics,undefined
[6] Inc.,undefined
[7] Genentech,undefined
来源：
Journal of Translational Medicine | / 21卷
关键词：
Frontotemporal dementia; Latozinemab; Neuroprotection; Phase 1 clinical trial; Pharmacodynamics; Pharmacokinetics; Progranulin; Safety; Sortilin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [21] Frontotemporal dementia in a large Swedish family is caused by a progranulin null mutation
    Lena Skoglund
    RoseMarie Brundin
    Tommie Olofsson
    Hannu Kalimo
    Sofie Ingvast
    Elin S. Blom
    Vilmantas Giedraitis
    Martin Ingelsson
    Lars Lannfelt
    Hans Basun
    Anna Glaser
    neurogenetics, 2009, 10 : 27 - 34
  • [22] Loss of exosomes in progranulin-associated frontotemporal dementia
    Benussi, Luisa
    Ciani, Miriam
    Tonoli, Elisa
    Morbin, Michela
    Palamara, Luisa
    Albani, Diego
    Fusco, Federica
    Forloni, Gianluigi
    Glionna, Michela
    Baco, Monika
    Paterlini, Anna
    Fostinelli, Silvia
    Santini, Benedetta
    Galbiati, Elisabetta
    Gagni, Paola
    Cretich, Marina
    Binetti, Giuliano
    Tagliavini, Fabrizio
    Prosperi, Davide
    Chiari, Marcella
    Ghidoni, Roberta
    NEUROBIOLOGY OF AGING, 2016, 40 : 41 - 49
  • [23] Lysosomal functions of progranulin and implications for treatment of frontotemporal dementia
    Simon, Matthew J.
    Logan, Todd
    DeVos, Sarah L.
    Di Paolo, Gilbert
    TRENDS IN CELL BIOLOGY, 2023, 33 (04) : 324 - 339
  • [24] Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis
    Arrant, Andrew E.
    Onyilo, Vincent C.
    Unger, Daniel E.
    Roberson, Erik D.
    JOURNAL OF NEUROSCIENCE, 2018, 38 (09) : 2341 - 2358
  • [25] Characterization of Progranulin Gene Mutations in Portuguese Patients with Frontotemporal Dementia
    Almeida, Maria Rosario
    Tabuas-Pereira, Miguel
    Baldeiras, Ines
    Lima, Marisa
    Duraes, Joao
    Massano, Joao
    Pinto, Madalena
    Cruto, Catarina
    Santana, Isabel
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (01)
  • [26] Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia
    Holler, Christopher J.
    Taylor, Georgia
    McEachin, Zachary T.
    Deng, Qiudong
    Watkins, William J.
    Hudson, Kathryn
    Easley, Charles A.
    Hu, William T.
    Hales, Chadwick M.
    Rossoll, Wilfried
    Bassell, Gary J.
    Kukar, Thomas
    MOLECULAR NEURODEGENERATION, 2016, 11
  • [27] Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia
    Christopher J. Holler
    Georgia Taylor
    Zachary T. McEachin
    Qiudong Deng
    William J. Watkins
    Kathryn Hudson
    Charles A. Easley
    William T. Hu
    Chadwick M. Hales
    Wilfried Rossoll
    Gary J. Bassell
    Thomas Kukar
    Molecular Neurodegeneration, 11
  • [28] Pathological correlates of white matter hyperintensities in a case of progranulin mutation associated frontotemporal dementia
    Woollacott, Ione O. C.
    Bocchetta, Martina
    Sudre, Carole H.
    Ridha, Basil H.
    Strand, Catherine
    Courtney, Robert
    Ourselin, Sebastien
    Cardoso, M. Jorge
    Warren, Jason D.
    Rossor, Martin N.
    Revesz, Tamas
    Fox, Nick C.
    Holton, Janice L.
    Lashley, Tammaryn
    Rohrer, Jonathan D.
    NEUROCASE, 2018, 24 (03) : 166 - 174
  • [29] Traumatic Brain Injury May Increase the Risk for Frontotemporal Dementia through Reduced Progranulin
    Jawaid, Ali
    Rademakers, Rosa
    Kass, Joseph S.
    Kalkonde, Yogeshwar
    Schulz, Paul E.
    NEURODEGENERATIVE DISEASES, 2009, 6 (5-6) : 219 - 220
  • [30] Suberoylanilide hydroxamic acid increases progranulin production in iPSC-derived cortical neurons of frontotemporal dementia patients
    Almeida, Sandra
    Gao, Fuying
    Coppola, Giovanni
    Gao, Fen-Biao
    NEUROBIOLOGY OF AGING, 2016, 42 : 35 - 40
12345