Intracavernosal injections of vascular endothelial growth factor protects endothelial dependent corpora cavernosal smooth muscle relaxation in the hypercholesterolemic rabbit: a preliminary study

被引：0

作者：

GD Henry

R Byrne

TTT Hunyh

V Abraham

BH Annex

PO Hagen

CF Donatucci

机构：

[1] Duke University Medical Center,Division of Urology, Department of Medicine

[2] Atherosclerosis Research Laboratory,Division of General and Thoracic Surgery, Department of Surgery

[3] Duke University Medical Center,Division of Cardiology, Department of Medicine

[4] Duke University Medical Center,undefined

来源：

International Journal of Impotence Research | 2000年 / 12卷

关键词：

nitric oxide; vascular endothelial growth factor; erectile dysfunction; rabbit; penis; impotence; nitric oxide synthase; hypercholesterolemia;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Atherosclerosis is a major risk factor for erectile dysfunction, and loss of endothelium-dependent vasodilation appears early in the development of this disorder. Nitric oxide (NO) appears to be the principle mediator of erectile function and is generated in part by the sinusoidal endothelium. Vascular endothelial growth factor (VEGF) is an angiogenic growth factor and an endothelial cell-specific mitogen and the actions of VEGF are coupled to NO. In this preliminary study, we investigated whether VEGF could be used to protect endothelial dependent cavernosal relaxation from the atherosclerotic injury induced by a hypercholesterolemic diet.

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页码：334 / 339

页数：5

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