Intracavernosal injections of vascular endothelial growth factor protects endothelial dependent corpora cavernosal smooth muscle relaxation in the hypercholesterolemic rabbit: a preliminary study

被引：0
|
作者：
GD Henry
R Byrne
TTT Hunyh
V Abraham
BH Annex
PO Hagen
CF Donatucci
机构：
[1] Duke University Medical Center,Division of Urology, Department of Medicine
[2] Atherosclerosis Research Laboratory,Division of General and Thoracic Surgery, Department of Surgery
[3] Duke University Medical Center,Division of Cardiology, Department of Medicine
[4] Duke University Medical Center,undefined
来源：
International Journal of Impotence Research | 2000年 / 12卷
关键词：
nitric oxide; vascular endothelial growth factor; erectile dysfunction; rabbit; penis; impotence; nitric oxide synthase; hypercholesterolemia;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Atherosclerosis is a major risk factor for erectile dysfunction, and loss of endothelium-dependent vasodilation appears early in the development of this disorder. Nitric oxide (NO) appears to be the principle mediator of erectile function and is generated in part by the sinusoidal endothelium. Vascular endothelial growth factor (VEGF) is an angiogenic growth factor and an endothelial cell-specific mitogen and the actions of VEGF are coupled to NO. In this preliminary study, we investigated whether VEGF could be used to protect endothelial dependent cavernosal relaxation from the atherosclerotic injury induced by a hypercholesterolemic diet.
引用
收藏
页码：334 / 339
页数：5
相关论文
共 50 条
  • [1] Intracavernosal injections of vascular endothelial growth factor protects endothelial dependent corpora cavernosal smooth muscle relaxation in the hypercholesterolemic rabbit: a preliminary study
    Henry, GD
    Byrne, R
    Hunyh, TTT
    Abraham, V
    Annex, BH
    Hagen, PO
    Donatucci, CF
    INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH, 2000, 12 (06) : 334 - 339
  • [2] Involvement of endothelial nitric oxide synthase in the impaired endothelium-dependent relaxation of cavernous smooth muscle in hypercholesterolemic rabbit
    Seo, KK
    Yun, HY
    Kim, H
    Kim, SC
    JOURNAL OF ANDROLOGY, 1999, 20 (02): : 298 - 306
  • [3] Vascular endothelial growth factor restores corporeal smooth muscle function in vitro
    Byrne, RR
    Henry, GD
    Rao, DS
    Huynh, TTT
    Pippen, AM
    Annex, BH
    Hagen, PO
    Donatucci, CF
    JOURNAL OF UROLOGY, 2001, 165 (04) : 1310 - 1315
  • [4] Statins differentially regulate vascular endothelial growth factor synthesis in endothelial and vascular smooth muscle cells
    Frick, M
    Dulak, J
    Cisowski, J
    Józkowicz, A
    Zwick, R
    Alber, H
    Dichtl, W
    Schwarzacher, SP
    Pachinger, O
    Weidinger, F
    ATHEROSCLEROSIS, 2003, 170 (02) : 229 - 236
  • [5] Vascular endothelial growth factor-induced migration of vascular smooth muscle cells in vitro
    Grosskreutz, CL
    Anand-Apte, B
    Dupláa, C
    Quinn, TP
    Terman, BI
    Zetter, B
    D'Amore, PA
    MICROVASCULAR RESEARCH, 1999, 58 (02) : 128 - 136
  • [6] Cyclic stretch induces the expression of vascular endothelial growth factor in vascular smooth muscle cells
    Smith, JD
    Davies, N
    Willis, AI
    Sumpio, BE
    Zilla, P
    ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH, 2001, 8 (01): : 41 - 48
  • [7] Vascular endothelial growth factor promotes proliferation and migration of cavernous smooth muscle cells
    Liu, XW
    Lin, CS
    Graziottin, T
    Resplande, J
    Lue, TF
    JOURNAL OF UROLOGY, 2001, 166 (01) : 354 - 360
  • [8] Intercellular communication between vascular smooth muscle and endothelial cells mediated by heparin-binding epidermal growth factor-like growth factor and vascular endothelial growth factor
    Abramovitch, R
    Neeman, M
    Reich, R
    Stein, I
    Keshet, E
    Abraham, J
    Solomon, A
    Marikovsky, M
    FEBS LETTERS, 1998, 425 (03) : 441 - 447
  • [9] Insulin activates vascular endothelial growth factor in vascular smooth muscle cells: influence of nitric oxide and of insulin resistance
    Doronzo, G
    Russo, I
    Mattiello, L
    Anfossi, G
    Bosia, A
    Trovati, M
    EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2004, 34 (10) : 664 - 673
  • [10] Vascular endothelial growth factor inhibits mitogen-induced vascular smooth muscle cell proliferation
    Dorafshar, AH
    Angle, N
    Bryer-Ash, M
    Huang, DS
    Farooq, MM
    Gelabert, HA
    Freischlag, JA
    JOURNAL OF SURGICAL RESEARCH, 2003, 114 (02) : 179 - 186
12345