Backbone 1H, 15N, and 13C resonance assignments for the NOXO1β PX domain

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作者
Nicole Y. Davis
Linda C. McPhail
David A. Horita
机构
[1] Wake Forest University School of Medicine,Department of Biochemistry
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关键词
PX domain; NOXO1; NADPH oxidase; NMR backbone assignments;
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摘要
NOXO1 (Nox Organizer 1) is a homolog of the NAPDH oxidase protein p47phox. NADPH oxidases transfer electrons from NADPH to molecular oxygen, generating the superoxide anion. NOXO1 contains an N-terminal PX (phox homology) domain and is one of several PX domain-containing proteins found in the cytosolic subunits of the NADPH oxidase complex. These PX domains bind to membrane lipids and target the protein to membranes, recruiting other cytosolic components to the membrane bound components and aiding formation of a active enzyme complex. This recruitment represents a level of regulation of these oxidases. Here we report the backbone assignments of NOXO1β PX.
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页码:139 / 141
页数:2
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