Small heat shock proteins in neurodegenerative diseases

被引：0
作者：
Leen Vendredy
Elias Adriaenssens
Vincent Timmerman
机构：
[1] University of Antwerp,Department of Biomedical Sciences and Institute Born Bunge, Peripheral Neuropathy Research Group
来源：
Cell Stress and Chaperones | 2020年 / 25卷
关键词：
Small heat shock proteins; Hereditary peripheral neuropathies; Diseases of the central nervous system; Neurodegeneration; Protein aggregation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Small heat shock proteins are ubiquitously expressed chaperones, yet mutations in some of them cause tissue-specific diseases. Here, we will discuss how small heat shock proteins give rise to neurodegenerative disorders themselves while we will also highlight how these proteins can fulfil protective functions in neurodegenerative disorders caused by protein aggregation. The first half of this paper will be focused on how mutations in HSPB1, HSPB3, and HSPB8 are linked to inherited peripheral neuropathies like Charcot-Marie-Tooth (CMT) disease and distal hereditary motor neuropathy (dHMN). The second part of the paper will discuss how small heat shock proteins are linked to neurodegenerative disorders like Alzheimer’s, Parkinson’s, and Huntington’s disease.
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页码：679 / 699
页数：20
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