VilazodoneIn Major Depressive Disorder

被引:0
作者
James E. Frampton
机构
[1] Adis,
[2] a Wolters Kluwer Business,undefined
来源
CNS Drugs | 2011年 / 25卷
关键词
Major Depressive Disorder; Selective Serotonin Reuptake Inhibitor; Forced Swimming Test; MADRS Total Score; Vilazodone;
D O I
暂无
中图分类号
学科分类号
摘要
Vilazodone, a novel antidepressant agent that combines selective serotonin reuptake inhibitor (SSRI) activity and serotonin 5-HT1A receptor partial agonist activity in a single molecule, is indicated for the treatment of major depressive disorder (MDD) in the US. It is administered orally, once daily, with food.
引用
收藏
页码:615 / 627
页数:12
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  • [21] Terao T(1997)EMD 68843, a serotonin reuptake inhibitor with selective presynaptic 5-HT1A receptor agonistic properties Eur J Pharmacol 322 147-53
  • [22] Cowen P(2004)Synthesis and structure-activity relationship in a class of indole-butylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors J Med Chem 47 4684-92
  • [23] Blier P(2001)Systemic EMD 68843 injections reduce anxiety in the shock-probe, but not the plus-maze test Eur J Pharmacol 414 245-8
  • [24] Bergeron R(2000)Drug action at the 5-HT(1A) receptor in vivo: autoreceptor and postsynaptic receptor occupancy examined with PET and carbonyl-(11)C Nucl Med Biol 27 509-13
  • [25] Khan A(2001)Distinct temporal pattern of the effects of the combined serotonin-reuptake inhibitor and 5-HT1A agonist EMD 68843 on the sleep EEG in healthy men Psychopharmacology (Berl) 155 187-92
  • [26] Howland RH(2009)Evidence for efficacy and tolerability of vilazodone in the treatment of major depressive disorder: a randomized, double-blind, placebo-controlled trial J Clin Psychiatry 70 326-33
  • [27] Rickels K(2011)A randomized, double-blind, placebo-controlled, 8-week study of vilazodone, a serotonergic agent for the treatment of major depressive disorder J Clin Psychiatry 72 441-7
  • [28] Athanasiou M(undefined)undefined undefined undefined undefined-undefined
  • [29] Reed C(undefined)undefined undefined undefined undefined-undefined
  • [30] de Paulis T(undefined)undefined undefined undefined undefined-undefined