Pre-apoptotic response to therapeutic DNA damage involves protein modulation of Mcl-1, Hdm2 and Flt3 in acute myeloid leukemia cells

[1] Smith M(2004)Adult acute myeloid leukaemia Crit Rev Oncol Hematol 50 197-222

[2] Barnett M(1999)A simple, robust, validated and highly predictive index for the determination of risk-directed therapy in acute myeloid leukaemia derived from the MRC AML 10 trial. United Kingdom Medical Research Council's Adult and Childhood Leukaemia Working Parties Br J Haematol 107 69-79

[3] Bassan R(2006)A distinct p53 protein isoform signature reflects the onset of induction chemotherapy for acute myeloid leukemia Clin Cancer Res 12 3985-3992

[4] Gatta G(1995)Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals Cell 82 405-414

[5] Tondini C(2005)Role of early plasma membrane events in chemotherapy-induced cell death Drug Resistance Updates 8 5-14

[6] Kern W(2001)Signaling pathways activated by daunorubicin Blood 98 913-924

[7] Wheatley K(2006)Treatment for Acute Myelogenous Leukemia by Low-Dose, Total-Body, Irradiation-Based Conditioning and Hematopoietic Cell Transplantation From Related and Unrelated Donors J Clin Oncol 24 444-453

[8] Burnett AK(2006)131I-anti-CD45 antibody plus busulfan and cyclophosphamide before allogeneic hematopoietic cell transplantation for treatment of acute myeloid leukemia in first remission Blood 107 2184-2191

[9] Goldstone AH(2001)Radiotherapy and cellular signalling The Lancet Oncology 2 366-370

[10] Gray RG(1999)Effects of gamma-irradiation on acute myelogenous leukemia blasts: in vitro studies of proliferation, constitutive cytokine secretion, and accessory cell function during T cell activation J Hematother Stem Cell Res 8 431-441

[1] Smith M(2004)Adult acute myeloid leukaemia Crit Rev Oncol Hematol 50 197-222

[2] Barnett M(1999)A simple, robust, validated and highly predictive index for the determination of risk-directed therapy in acute myeloid leukaemia derived from the MRC AML 10 trial. United Kingdom Medical Research Council's Adult and Childhood Leukaemia Working Parties Br J Haematol 107 69-79

[3] Bassan R(2006)A distinct p53 protein isoform signature reflects the onset of induction chemotherapy for acute myeloid leukemia Clin Cancer Res 12 3985-3992

[4] Gatta G(1995)Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals Cell 82 405-414

[5] Tondini C(2005)Role of early plasma membrane events in chemotherapy-induced cell death Drug Resistance Updates 8 5-14

[6] Kern W(2001)Signaling pathways activated by daunorubicin Blood 98 913-924

[7] Wheatley K(2006)Treatment for Acute Myelogenous Leukemia by Low-Dose, Total-Body, Irradiation-Based Conditioning and Hematopoietic Cell Transplantation From Related and Unrelated Donors J Clin Oncol 24 444-453

[8] Burnett AK(2006)131I-anti-CD45 antibody plus busulfan and cyclophosphamide before allogeneic hematopoietic cell transplantation for treatment of acute myeloid leukemia in first remission Blood 107 2184-2191

[9] Goldstone AH(2001)Radiotherapy and cellular signalling The Lancet Oncology 2 366-370

[10] Gray RG(1999)Effects of gamma-irradiation on acute myelogenous leukemia blasts: in vitro studies of proliferation, constitutive cytokine secretion, and accessory cell function during T cell activation J Hematother Stem Cell Res 8 431-441