Interleukin-11, an IL-6-like cytokine

被引：0
作者：
Ch. D. Hook
D. V. Kuprash
机构：
[1] Russian Academy of Sciences,Engelhardt Institute of Molecular Biology
来源：
Molecular Biology | 2011年 / 45卷
关键词：
gp130; hematopoiesis; recombinant interleukin-11;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The aim of this review is to collect various data on different functions of interleukin-11 (IL-11), a member of a family of IL-6-like cytokines. Numerous in vitro experiments have suggested a long list of IL-11 properties including support and control of proliferation and differentiation of hematopoietic progenitors, as well as participation in osteoclastogenensis, neurogenesis, and development of some other tissues. However, a great number of in vitro effects of IL-11 have not been confirmed in experiments using murine models, hampering an understanding of the physiological role of this cytokine. We discuss possible reasons for the divergence between in vitro and in vivo data as well as the perspectives of using conditional gene targeting to assess the role of IL-11 in ontogenesis and immune response.
引用
收藏
页码：36 / 46
页数：10
相关论文
共 771 条
  • [1] Pflanz S.(2004)WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27 J. Immunol. 172 2225-2231
  • [2] Hibbert L.(2002)IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells Immunity 16 779-790
  • [3] Mattson J.(1997)1.9 of interleukin 6: Implications for a novel mode of receptor dimerization and signaling EMBO J 16 989-997
  • [4] Rosales R.(1995)Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing EMBO J 14 2689-2699
  • [5] Vaisberg E.(1994)The crystal structure and biological function of leukemia inhibitory factor: Implications for receptor binding Cell 77 1101-1116
  • [6] Bazan J.F.(1997)Signaling mechanisms through gp130: a model of the cytokine system Cytokine Growth Factor Rev 8 241-252
  • [7] Phillips J.H.(2003)GPL, a novel cytokine receptor related to GP130 and leukemia inhibitory factor receptor J. Biol. Chem. 278 49850-49859
  • [8] McClanahan T.K.(1990)Structural design and molecular evolution of a cytokine receptor superfamily Proc. Natl. Acad. Sci. U.S.A. 87 6934-6938
  • [9] de Waal Malefyt R.(1997)Molecular modeling-guided mutagenesis of the extra-cellular part of gp130 leads to the identification of contact sites in the interleukin-6 (IL-6).IL-6 receptor.gp130 complex J. Biol. Chem. 272 23748-23757
  • [10] Kastelein R.A.(1999)Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/-mice: A direct role for Stat5 in Bcl-X(L) induction Cell 98 181-191
12345678910