Influence of Baseline Physical Activity as a Modifying Factor on COVID-19 Mortality: A Single-Center, Retrospective Study

被引：52

作者：

Salgado-Aranda R. ^{[1
]}

Pérez-Castellano N. ^{[1
,2
,3
,4
]}

Núñez-Gil I. ^{[1
]}

Orozco A.J. ^{[1
]}

Torres-Esquivel N. ^{[1
]}

Flores-Soler J. ^{[1
]}

Chamaisse-Akari A. ^{[1
]}

Mclnerney A. ^{[1
]}

Vergara-Uzcategui C. ^{[1
]}

Wang L. ^{[1
]}

González-Ferrer J.J. ^{[1
]}

Filgueiras-Rama D. ^{[1
]}

Cañadas-Godoy V. ^{[1
]}

Macaya-Miguel C. ^{[1
,2
,3
,4
]}

Pérez-Villacastín J. ^{[1
,2
,3
,4
]}

机构：

[1] Instituto Cardiovascular, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid

[2] Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid

[3] Facultad de Medicina de la Universidad Complutense de Madrid, Madrid

[4] Fundación para la Investigación Interhospitalaria Cardiovascular, Madrid

来源：

Infectious Diseases and Therapy | 2021年 / 10卷 / 2期

关键词：

COVID-19; Exercise; Physical activity; Physical training; SARS-CoV-2;

D O I：

10.1007/s40121-021-00418-6

中图分类号：

学科分类号：

摘要：

Introduction: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes a severe respiratory disease with a 3% global mortality. In the absence of effective treatment, controlling of risk factors that predispose to severe disease is essential to reduce coronavirus disease 2019 (COVID-19) mortality. Large observational studies suggest that exercise can reduce the risk of all-cause and disease-specific mortality. The aim of this study was to analyze the influence of the baseline physical activity level on COVID-19 mortality Methods: This is a retrospective cohort study that included patients between 18 and 70 years old, diagnosed with COVID-19 and hospitalized in our center between February 15 and April 15, 2020. After discharge all the patients included in the study were contacted by telephone. Baseline physical activity level was estimated using the Rapid Assessment of Physical Activity Scale questionnaire and patients were divided into two groups for comparison: sedentary patients (group 1) and active patients (group 2). Results: During the study period 552 patients were admitted to our hospital and met the inclusion criteria. Global mortality in group 1 was significantly higher than in group 2 (13.8% vs 1.8%; p < 0.001). Patients with a sedentary lifestyle had increased COVID-19 mortality independently of other risk factors previously described (hazard ratio 5.91 (1.80–19.41); p = 0.003). Conclusion: A baseline sedentary lifestyle increases the mortality of hospitalized patients with COVID-19. This finding may be of great utility in the prevention of severe COVID-19 disease. © 2021, The Author(s).

引用

页码：801 / 814

页数：13

共 32 条

[1]

Huang C., Wang Y., Li X., Et al., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet, 395, 10223, pp. 497-506, (2020)

[2]

Sanidad M., Consumo Y Bienestar Social—Professionals—Situación Actual Coronavirus, (2020)

[3]

Zhou F., Yu T., Du R., Et al., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study, Lancet, 395, 10229, pp. 1054-1062, (2020)

[4]

Zheng Y.Y., Ma Y.T., Zhang J.Y., Xie X., COVID-19 and the cardiovascular system, Nat Rev Cardiol, 17, pp. 259-260, (2020)

[5]

Li B., Yang J., Zhao F., Et al., Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China, Clin Res Cardiol, 109, pp. 531-538, (2020)

[6]

Tartof S.Y., Qian L., Hong V., Et al., Obesity and mortality among patients diagnosed with COVID-19: results from an integrated health care organization, Ann Intern Med, 173, pp. 773-781, (2020)

[7]

Williamson E.J., Walker A.J., Bhaskaran K., Et al., Factors associated with COVID-19-related death using OpenSAFELY, Nature, 584, 7821, pp. 430-436, (2020)

[8]

Lighter J., Phillips M., Hochman S., Et al., Obesity in patients younger than 60 years is a risk factor for COVID-19 hospital admission, Clin Infect Dis, 71, pp. 896-897, (2020)

[9]

Chow N., Fleming-Dutra K., Gierke R., Et al., Preliminary estimates of the prevalence of selected underlying health conditions among patients with coronavirus disease 2019—United States, February 12–March 28, 2020, MMWR Morb Mortal Wkly Rep, 69, 13, pp. 382-386, (2020)

[10]

Liang W., Guan W., Chen R., Et al., Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China, Lancet Oncol, 21, pp. 335-337, (2020)

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