Novel and convenient synthesis of 5-benzoyl-1,4-naphthoquinone and its derivatives

被引：0
作者：
Jin Cai
Yong Li
Junqing Chen
Peng Wang
Min Ji
机构：
[1] Southeast University,School of Chemistry and Chemical Engineering, Institute of Pharmaceutical Engineering
[2] Southeast University,School of Chemistry and Chemical Engineering
来源：
Research on Chemical Intermediates | 2015年 / 41卷
关键词：
5-Benzoyl-1,4-naphthoquinone; Naphthoquinone; Synthesis; Antitumor; Sperm-killing;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A novel and convenient method for the preparation of 5-benzoyl-1,4-naphthoquinone is reported for the first time. The process starts with condensation of malonic acid, followed by Diers–Alder cyclization, methylation, aromatization, hydrolysis, Friedel–Crafts acylation, and oxidation. The new synthesis procedure with high yields does not require special conditions and column chromatographic purification. The method involves readily available reagents and has been demonstrated to be suitable for large-scale preparation.
引用
收藏
页码：1 / 9
页数：8
相关论文
共 47 条
[1]  
Kim BH(2006)undefined Arch. Pharm. Res. 29 123-195
[2]  
Yoo J(1984)undefined Cancer Res. 44 1928-undefined
[3]  
Park SH(1986)undefined Eur. J. Cancer Clin. Oncol. 22 921-undefined
[4]  
Jung JK(1995)undefined Reprod. Contracept. 15 260-undefined
[5]  
Cho H(1935)undefined Chem. Ber. 68 2034-undefined
[6]  
Chung Y(1986)undefined J. Org. Chem. 51 1921-undefined
[7]  
Leopold WR(1997)undefined Acta Crystallogr. C 53 1077-undefined
[8]  
Shillis JL(1980)undefined J. Am. Chem. Soc. 102 6114-undefined
[9]  
Mertus AE(2009)undefined J. Org. Chem. 74 5987-undefined
[10]  
Nelson JM(2003)undefined J. Am. Chem. Soc. 125 2489-undefined
12345