What is antiphospholipid syndrome?

被引：23
作者：
Erkan D. [1 ]
Lockshin M.D. [1 ]
机构：
[1] Department of Rheumatolopgy, Hospital for Special Surgery, 535 E 70th Street, New York, 10021, NY
来源：
Current Rheumatology Reports | 2004年 / 6卷 / 6期
关键词：
Anticardiolipin Antibody; Factor Versus Leiden Mutation; Pregnancy Morbidity; Thrombotic Risk Factor; Lupus Anticoagulant Test;
D O I：
10.1007/s11926-004-0024-1
中图分类号：
学科分类号：
摘要：
The description of antiphospholipid syndrome (APS) is vascular thrombosis and/or pregnancy morbidity occurring in persons with antiphospholipid antibodies (aPL). However, because of an unclear etiopathogenesis and the heterogeneous nature of aPL and of aPL-related clinical manifestations, a single, unambiguous definition of APS does not exist. In this paper, we describe a structured approach to APS, discuss the controversies, and offer descriptions of APS that include: an autoimmune systemic disease with a spectrum of (mostly thrombotic) clinical manifestations, an overdiagnosed disease when aPL is present but has no proven direct causative role in the clinical manifestations, and a disease of controversies that requires clarification of etiology and mechanisms and risk-stratified controlled clinical studies.
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收藏
页码：451 / 457
页数：6
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