Obesity Treatment with Botulinum Toxin-A Is Not Effective: a Systematic Review and Meta-Analysis

被引：0
作者：
Fabio Bustamante
Vitor Ottoboni Brunaldi
Wanderley Marques Bernardo
Diogo Turiani H. de Moura
Eduardo Turiani H. de Moura
Manoel Galvão
Marco Aurélio Santo
Eduardo Guimarães H. de Moura
机构：
[1] University of São Paulo Medical School,Gastrointestinal Endoscopy Unit, Hospital das Clinicas
[2] Unit of Endoscopy - Gastro Obeso Center,Bariatric and Metabolic Surgery Unit, Hospital das Clinicas
[3] University of Sao Paulo Medical School,undefined
来源：
Obesity Surgery | 2017年 / 27卷
关键词：
Obesity; Botulinum toxins; Endoscopy; Gastric emptying; Systematic review; Meta-analysis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The effectiveness of gastric injections of botulinum toxin-A (BTA) as primary treatment for obesity is not well known since results in literature are discrepant. Hence, we aimed to systematically review and meta-analyze the available data to assess the real effect of BTA therapy. We searched MEDLINE, Embase, Cochrane, SCOPUS, EBSCO, LILACS, and BVS. We considered eligible only randomized controlled trials enrolling obese patients comparing BTA versus saline injections. Our initial search identified 8811 records. Six studies fulfilled eligibility criteria. After critical appraisal, two articles were excluded and we meta-analyzed the remainder. The mean difference for absolute weight loss and BMI reduction were 0.12 [CI 95%, − 1.14, 1.38] and − 0.06 [95% CI, − 0.92, 0.81], respectively. Therefore, we concluded that treatment of obesity with BTA is not effective.
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页码：2716 / 2723
页数：7
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