Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents

被引：0
作者：
Nicole E Burma
Robert P Bonin
Heather Leduc-Pessah
Corey Baimel
Zoe F Cairncross
Michael Mousseau
Jhenkruthi Vijaya Shankara
Patrick L Stemkowski
Dinara Baimoukhametova
Jaideep S Bains
Michael C Antle
Gerald W Zamponi
Catherine M Cahill
Stephanie L Borgland
Yves De Koninck
Tuan Trang
机构：
[1] University of Calgary,Department of Comparative Biology and Experimental Medicine
[2] Hotchkiss Brain Institute,Department of Physiology and Pharmacology
[3] University of Calgary,Department of Pharmaceutical Sciences
[4] Leslie Dan Faculty of Pharmacy,Department of Psychology
[5] University of Toronto,Department of Anesthesiology and Perioperative Care
[6] University of Calgary,Department of Psychiatry and Neuroscience
[7] University of California Irvine,undefined
[8] Institut Universitaire en santé mentale de Québec,undefined
[9] Université Laval,undefined
来源：
Nature Medicine | 2017年 / 23卷
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D O I：
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中图分类号：
学科分类号：
摘要：
The release of ATP from spinal microglia via pannexin-1 channels is required for withdrawal symptoms after termination of chronic opioid treatment in rodents, and pharmacological blockade of pannexin-1 channels reduces the severity of withdrawal without affecting opiate analgesia.
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页码：355 / 360
页数：5
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