Signaling pathways in cancer metabolism: mechanisms and therapeutic targets

被引：0
作者：
Mengshu You
Zhuolin Xie
Nan Zhang
Yixuan Zhang
Desheng Xiao
Shuang Liu
Wei Zhuang
Lili Li
Yongguang Tao
机构：
[1] Central South University,Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine
[2] Central South University,NHC Key Laboratory of Carcinogenesis (Central South University), Cancer Research Institute and School of Basic Medicine
[3] Central South University,Department of Pathology, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Xiangya Hospital
[4] Central South University,Department of Pathology, Xiangya Hospital
[5] Central South University,Department of Oncology, Institute of Medical Sciences, Xiangya Hospital
[6] Central South University,Department of Thoracic Surgery, Xiangya Hospital
[7] The Chinese University of Hong Kong,Cancer Epigenetics Laboratory, Department of Clinical Oncology, State Key Laboratory of Translational Oncology, Sir YK Pao Centre for Cancer and Li Ka Shing Institute of Health Sciences
[8] Central South University,Department of Thoracic Surgery, Hunan Key Laboratory of Early Diagnosis and Precision Therapy in Lung Cancer, Second Xiangya Hospital
来源：
Signal Transduction and Targeted Therapy | / 8卷
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摘要：
A wide spectrum of metabolites (mainly, the three major nutrients and their derivatives) can be sensed by specific sensors, then trigger a series of signal transduction pathways and affect the expression levels of genes in epigenetics, which is called metabolite sensing. Life body regulates metabolism, immunity, and inflammation by metabolite sensing, coordinating the pathophysiology of the host to achieve balance with the external environment. Metabolic reprogramming in cancers cause different phenotypic characteristics of cancer cell from normal cell, including cell proliferation, migration, invasion, angiogenesis, etc. Metabolic disorders in cancer cells further create a microenvironment including many kinds of oncometabolites that are conducive to the growth of cancer, thus forming a vicious circle. At the same time, exogenous metabolites can also affect the biological behavior of tumors. Here, we discuss the metabolite sensing mechanisms of the three major nutrients and their derivatives, as well as their abnormalities in the development of various cancers, and discuss the potential therapeutic targets based on metabolite-sensing signaling pathways to prevent the progression of cancer.
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