Application of Clinical Trial Simulation to Compare Proof-of-Concept Study Designs for Drugs with a Slow Onset of Effect; An Example in Alzheimer's Disease

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作者
Peter Lockwood
Wayne Ewy
David Hermann
Nick Holford
机构
[1] Pfizer Global Research and Development,Department of Pharmacology and Clinical Pharmacology, School of Medicine
[2] deCODE genetics,undefined
[3] University of Auckland,undefined
来源
Pharmaceutical Research | 2006年 / 23卷
关键词
Alzheimer's disease; clinical trial simulation; pharmacokinetic pharmacodynamic model; trial design;
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