Structural basis of kynurenine 3-monooxygenase inhibition

被引：0
|
作者：
Marta Amaral
Colin Levy
Derren J. Heyes
Pierre Lafite
Tiago F. Outeiro
Flaviano Giorgini
David Leys
Nigel S. Scrutton
机构：
[1] Manchester Institute of Biotechnology,Department of Genetics
[2] The University of Manchester,Department of Neurodegeneration and Restorative Research
[3] University of Leicester,undefined
[4] Cell and Molecular Neuroscience Unit,undefined
[5] Instituto de Medicina Molecular,undefined
[6] Instituto de Fisiologia,undefined
[7] Institut de Chimie Organique et Analytique,undefined
[8] Université d’Orléans,undefined
[9] CNRS UMR 7311 BP6769,undefined
[10] Rue de Chartres,undefined
[11] 45067 Orléans Cedex 2,undefined
[12] France,undefined
[13] Center for Nanoscale Microscopy and Molecular Physiology of the Brain,undefined
[14] University Medical Center Göttingen,undefined
[15] Waldweg 33,undefined
[16] 37073 Göttingen,undefined
[17] Germany,undefined
来源：
Nature | 2013年 / 496卷
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学科分类号：
摘要：
Inhibition of kynurenine 3-monooxygenase (KMO) leads to amelioration of Huntington’s-disease-relevant phenotypes in yeast, fruitfly and mouse models; here the crystal structures of free and inhibitor-bound yeast KMO are presented, which could aid the development of targeted therapies for human neurodegenerative diseases.
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页码：382 / 385
页数：3
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