Structural basis of kynurenine 3-monooxygenase inhibition

被引：0

作者：

Marta Amaral

Colin Levy

Derren J. Heyes

Pierre Lafite

Tiago F. Outeiro

Flaviano Giorgini

David Leys

Nigel S. Scrutton

机构：

[1] Manchester Institute of Biotechnology,Department of Genetics

[2] The University of Manchester,Department of Neurodegeneration and Restorative Research

[3] University of Leicester,undefined

[4] Cell and Molecular Neuroscience Unit,undefined

[5] Instituto de Medicina Molecular,undefined

[6] Instituto de Fisiologia,undefined

[7] Institut de Chimie Organique et Analytique,undefined

[8] Université d’Orléans,undefined

[9] CNRS UMR 7311 BP6769,undefined

[10] Rue de Chartres,undefined

[11] 45067 Orléans Cedex 2,undefined

[12] France,undefined

[13] Center for Nanoscale Microscopy and Molecular Physiology of the Brain,undefined

[14] University Medical Center Göttingen,undefined

[15] Waldweg 33,undefined

[16] 37073 Göttingen,undefined

[17] Germany,undefined

来源：

Nature | 2013年 / 496卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Inhibition of kynurenine 3-monooxygenase (KMO) leads to amelioration of Huntington’s-disease-relevant phenotypes in yeast, fruitfly and mouse models; here the crystal structures of free and inhibitor-bound yeast KMO are presented, which could aid the development of targeted therapies for human neurodegenerative diseases.

引用

页码：382 / 385

页数：3

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