Structural basis of kynurenine 3-monooxygenase inhibition

被引：0

作者：

Marta Amaral

Colin Levy

Derren J. Heyes

Pierre Lafite

Tiago F. Outeiro

Flaviano Giorgini

David Leys

Nigel S. Scrutton

机构：

[1] Manchester Institute of Biotechnology,Department of Genetics

[2] The University of Manchester,Department of Neurodegeneration and Restorative Research

[3] University of Leicester,undefined

[4] Cell and Molecular Neuroscience Unit,undefined

[5] Instituto de Medicina Molecular,undefined

[6] Instituto de Fisiologia,undefined

[7] Institut de Chimie Organique et Analytique,undefined

[8] Université d’Orléans,undefined

[9] CNRS UMR 7311 BP6769,undefined

[10] Rue de Chartres,undefined

[11] 45067 Orléans Cedex 2,undefined

[12] France,undefined

[13] Center for Nanoscale Microscopy and Molecular Physiology of the Brain,undefined

[14] University Medical Center Göttingen,undefined

[15] Waldweg 33,undefined

[16] 37073 Göttingen,undefined

[17] Germany,undefined

来源：

Nature | 2013年 / 496卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Inhibition of kynurenine 3-monooxygenase (KMO) leads to amelioration of Huntington’s-disease-relevant phenotypes in yeast, fruitfly and mouse models; here the crystal structures of free and inhibitor-bound yeast KMO are presented, which could aid the development of targeted therapies for human neurodegenerative diseases.

引用

页码：382 / 385

页数：3

共 50 条

[1] Structural basis of kynurenine 3-monooxygenase inhibition
Amaral, Marta
Levy, Colin
Heyes, Derren J.
Lafite, Pierre
Outeiro, Tiago F.
Giorgini, Flaviano
Leys, David
Scrutton, Nigel S.
NATURE, 2013, 496 (7445) : 382 - +
[2] Inhibition of kynurenine 3-monooxygenase in EAE
Oezen, Iris
Mildenberger, Iris
Platten, Michael
JOURNAL OF NEUROIMMUNOLOGY, 2014, 275 (1-2) : 127 - 127
[3] Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration
Zwilling, Daniel
Huang, Shao-Yi
Sathyasaikumar, Korrapati V.
Notarangelo, Francesca M.
Guidetti, Paolo
Wu, Hui-Qiu
Lee, Jason
Truong, Jennifer
Andrews-Zwilling, Yaisa
Hsieh, Eric W.
Louie, Jamie Y.
Wu, Tiffany
Scearce-Levie, Kimberly
Patrick, Christina
Adame, Anthony
Giorgini, Flaviano
Moussaoui, Saliha
Laue, Grit
Rassoulpour, Arash
Flik, Gunnar
Huang, Yadong
Muchowski, Joseph M.
Masliah, Eliezer
Schwarcz, Robert
Muchowski, Paul J.
CELL, 2011, 145 (06) : 863 - 874
[4] The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors
Hughes, Tamera D.
Guner, Osman F.
Iradukunda, Emma Carine
Phillips, Robert S.
Bowen, J. Phillip
MOLECULES, 2022, 27 (01):
[5] Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase
Kim, Hyun Tae
Na, Byeong Kwan
Chung, Jiwoung
Kim, Sulhee
Kwon, Sool Ki
Cha, Hyunju
Son, Jonghyeon
Cho, Joong Myung
Hwang, Kwang Yeon
CELL CHEMICAL BIOLOGY, 2018, 25 (04): : 426 - +
[6] Kynurenine 3-monooxygenase: an influential mediator of neuropathology
Parrott, Jennifer M.
O'Connor, Jason C.
FRONTIERS IN PSYCHIATRY, 2015, 6
[7] Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048
Gao, Jingjing
Yao, Licheng
Xia, Tingting
Liao, Xuebin
Zhu, Deyu
Xiang, Ye
FASEB JOURNAL, 2018, 32 (04): : 2036 - 2045
[8] Kynurenine 3-Monooxygenase from Pseudomonas fluorescens
Moran, Graham R.
Reabe, Karen R.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 241
[9] Deficiency of kynurenine 3-monooxygenase exacerbates impairment of prepulse inhibition induced by phencyclidine
Kubota, Hisayoshi
Kunisawa, Kazuo
Niijima, Moe
Hirakawa, Mami
Mori, Yuko
Hasegawa, Masaya
Fujigaki, Suwako
Fujigaki, Hidetsugu
Yamamoto, Yasuko
Saito, Kuniaki
Nabeshima, Toshitaka
Mouri, Akihiro
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2022, 629 : 142 - 151
[10] Modelling the elusive conformational activation in kynurenine 3-monooxygenase
Oezkilic, Yilmaz
Stein, Matthias
ORGANIC & BIOMOLECULAR CHEMISTRY, 2024, 22 (32) : 6550 - 6560

← 1 2 3 4 5 →