The truncated splice variant of peroxisome proliferator-activated receptor alpha, PPARα-tr, autonomously regulates proliferative and pro-inflammatory genes

被引：0
作者：
Maria Thomas
Christine Bayha
Kathrin Klein
Simon Müller
Thomas S. Weiss
Matthias Schwab
Ulrich M. Zanger
机构：
[1] Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology,Department of Clinical Pharmacology
[2] Auerbachstr. 112,undefined
[3] 70736,undefined
[4] Stuttgart,undefined
[5] and University of Tuebingen,undefined
[6] University Children Hospital (KUNO),undefined
[7] Regensburg University Hospital,undefined
[8] University of Tuebingen,undefined
[9] Present address: MUON-STAT,undefined
来源：
BMC Cancer | / 15卷
关键词：
Alternative splicing; Fibrates; Hepatocarcinogenesis; PPARA; Primary human hepatocytes; Inflammation; Proliferation; WNT/β-catenin;
D O I：
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  • [41] Feldman PL(2012)The story so far: post-translational regulation of peroxisome proliferator-activated receptors by ubiquitination and SUMOylation Am J Physiol 302 1379-undefined
  • [42] Lambert MH(2012)PPARs at the crossroads of lipid signaling and inflammation Trends Endocrinol Metab 23 68-undefined
  • [43] Henke BR(2014)Minireview: Challenges and opportunities in development of PPAR agonists Mol Endocrinol 28 undefined-undefined
  • [44] Gervois P(2008)The PPAR?-Humanized Mouse: A Model to Investigate Species Differences in Liver Toxicity Mediated by PPAR? Toxicol Sci 101 undefined-undefined
  • [45] Torra IP(2007)Clofibric acid, a peroxisome proliferator-activated receptor alpha ligand, inhibits growth of human ovarian cancer Mol Cancer Ther 6 undefined-undefined
  • [46] Chinetti G(2011)Peroxisome proliferator-activated receptors and cancer: challenges and opportunities Br J Pharmacol 164 undefined-undefined
  • [47] Grötzinger T(undefined)undefined undefined undefined undefined-undefined
  • [48] Dubois G(undefined)undefined undefined undefined undefined-undefined
  • [49] Fruchart JC(undefined)undefined undefined undefined undefined-undefined
  • [50] Fruchart-Najib J(undefined)undefined undefined undefined undefined-undefined
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