Synthesis of 5-oxo-1-(5-R-1,3,4-thiadiazol-2-yl)pyrrolidine-3-carboxylic acids

被引：0
作者：
S. A. Serkov
N. V. Sigay
N. N. Kostikova
A. P. Tyurin
N. G. Kolotyrkina
G. A. Gazieva
机构：
[1] Russian Academy of Sciences,N. D. Zelinsky Institute of Organic Chemistry
[2] Russian Academy of Sciences,M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry
来源：
Russian Chemical Bulletin | 2023年 / 72卷
关键词：
2-amino-1,3,4-thiadiazoles; 5-oxopyrrolidine-3-carboxylic acid; heterocyclic ensembles; itaconic acid;
D O I：
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中图分类号：
学科分类号：
摘要：
A series of new heterocyclic ensembles, derivatives of 5-oxo-1-(1,3,4-thiadiazol-2-yl)-pyrrolidine-3-carboxylic acid, was synthesized by heating 5-substituted 1,3,4-thiadiazol-2-amines and itaconic acid under solvent-free conditions or with the addition of acetic acid at 140–150 °C. The resulting acids can be used as building blocks in the synthesis of new potentially biologically active heterocyclic compounds.
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页码：1837 / 1843
页数：6
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