Virus receptors in the human central nervous system

被引：0

作者：

Schweighardt B. ^{[1
]}

Atwood W.J. ^{[1
]}

机构：

[1] Dept. of Mol. Microbiol./Immunology, Brown University, Providence, RI 02912

来源：

Journal of NeuroVirology | 2001年 / 7卷 / 3期

关键词：

Rabies; Rabies Virus; Measle Virus; Human Central Nervous System; Virus Receptor;

D O I：

10.1080/13550280152403236

中图分类号：

学科分类号：

摘要：

The initial event in the life cycle of a virus is its interaction with receptors present on the surface of a cell. Understanding these interactions is important to our understanding of viral tropism, spread, and pathogenesis. This is particularly true of viruses that target the central nervous system as these viruses must maintain a tropism for both the nervous system and for peripheral organs that allow for viral replication and spread to new susceptible hosts. These viruses therefore interact with a diverse set of cells and tissues, interactions that are likely mediated by both common and unique receptors present on each target tissue. In addition, physiological changes in the host can lead to increased or decreased expression of virus receptors, which influence virus trafficking, spread, and tissue specific pathology. This review will focus on the relatively few virus receptor systems that have been described in some level of detail for viruses that target the human central nervous system.

引用

页码：187 / 195

页数：8

共 98 条

[1]

Albright A.V., Strizki J., Harouse J.M., Lavi E., O'Connor M., Gonzalez-Scarano F., HIV-1 infection of cultured human adult oligodendrocytes, Virology, 217, 1, pp. 211-219, (1996)

[2]

Alkhatib F., Combadiere C., Broder C., Feng Y., Kennedy P.E., Murphy P.M., Berger E.A., CC CKR5: A RANTES, MIP-1 alpha, MIP-1 beta receptor as a fusion cofactor for macrophage-tropic HIV-1, Science, 272, pp. 1955-1958, (1996)

[3]

An S.F., Groves M., Giometto B., Beckett A.A.J., Scaravelli F., Detection and localisation of HIV-1 DNA and RNA in fixed adult AIDS brain by polymerase chain reaction/insitu hybridization technique, Acta Neuropathol, 98, pp. 481-487, (1999)

[4]

An S.F., Groves M., Gray F., Scaravilli F., Early entry and widespread cellular involvement of HIV-1 DNA in brains of HIV-1 positive asymptomatic individuals, J Neuropathol Exp Neurol, 58, 11, pp. 1156-1162, (1999)

[5]

Atwood W.J., Berger J.R., Kaderman R., Tornatore C.S., Major E.O., Human immunodeficiency virus type 1 infection of the brain, Clin Microbiol Rev, 6, pp. 339-366, (1993)

[6]

Bagasra O., Lavi E., Bobroski L., Khalili K., Pestaner J.P., Pomerantz R.J., Cellular reservoirs of HIV-1 in the central nervous system of infected individuals: Identification by the combination of in situ PCR and immunohistochemistry, AIDS, 10, pp. 573-585, (1996)

[7]

Bearzotti M., Delmas B., Lamoureux A., Loustau A.M., Chilmonczyk S., Bremont M., Fish rhabdovirus cell entry is mediated by fibronectin, J Virol, 73, 9, pp. 7703-7709, (1999)

[8]

Blake F.G., Trask J.D., Studies on measles virus: I. Susceptibility of monkeys to the measles virus, J Exp Med, 33, pp. 385-412, (1921)

[9]

Blixenkrone-Moller M., Bernard A., Bencsik A., Sixt N., Diamond L.E., Logan J.S., Wild T.F., Role of CD46 in measles virus infection in CD46 transgenic mice, Virology, 249, 2, pp. 238-248, (1998)

[10]

Brack-Werner R., Astrocytes: HIV cellular reservoirs and important participants in neuropathogenesis, AIDS, 13, pp. 1-22, (1999)

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