Bone, brain & beyond

被引：0
作者：
Alexandre Chamouni
Christiane Schreiweis
Franck Oury
机构：
[1] Institut Necker-Enfants Malades (INEM),Centre de Médecine Moléculaire
[2] Institut National de la Santé et de la Recherche Médicale,undefined
[3] Université Paris Descartes,undefined
[4] INSERM U1151,undefined
[5] Institut Necker Enfants-Malades (INEM),undefined
来源：
Reviews in Endocrine and Metabolic Disorders | 2015年 / 16卷
关键词：
Bone; Brain; Osteocalcin; Whole-organism homeostasis; Behavior; Integrative physiology;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In the past 15 years, the field of physiology has been radically challenged by landmark studies using novel tools of genetic engineering. Particular to our interest, the reciprocal interactions between the skeleton and the nervous system were shown to be major ones. The demonstration that brain, via multiple pathways, is a powerful regulator of bone growth, has shed light on an important central regulation of skeletal homeostasis. More recently, it was shown that bone might return the favor to the brain through the secretion of a bone-derived hormone, osteocalcin. The skeleton influences development and cognitive functions of the central nervous system at different stages throughout life suggesting an intimate dialogue between bone and brain.
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页码：99 / 113
页数：14
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