The Hypothalamic-Pituitary-Adrenal Axis, Obesity, and Chronic Stress Exposure: Sleep and the HPA Axis in Obesity

被引：67

作者：

Lucassen E.A. ^{[1
]}

Cizza G. ^{[2
]}

机构：

[1] Laboratory of Neurophysiology, Department of Molecular Cell Biology, Leiden University Medical Center, Leiden

[2] Section on Neuroendocrinology of Obesity, NIDDK, National Institutes of Health, Bethesda, MD, 20892-1613, Building 10, CRC

来源：

Current Obesity Reports | 2012年 / 1卷 / 4期

关键词：

11β-hydroxysteroid dehydrogenase; ACTH; Body mass index; Cortisol; Cortisol binding globulin; CRH; Glucocorticoid; HPA-axis; Obesity; Sleep; Stress;

D O I：

10.1007/s13679-012-0028-5

中图分类号：

学科分类号：

摘要：

Obesity, exposure to stress and inadequate sleep are prevalent phenomena in modern society. In this review we focus on their relationships and critically evaluate causality. In obese individuals, one of the main stress systems, the hypothalamic-pituitary-adrenal axis, is altered, and concentrations of cortisol are elevated in adipose tissue due to elevated local activity of 11β-hydroxysteroid dehydrogenase (HSD) type 1. Short sleep and decreased sleep quality are also associated with obesity. In addition, experimental sleep curtailment induces HPA-axis alterations which, in turn, may negatively affect sleep. These findings implicate that obesity, stress and sleep loss are all related in a vicious circle. Finally, we discuss new strategies to combat obesity through modulating cortisol levels in adipose tissue by 11β-HSD1 inhibitors or by improving sleep duration. © 2012 Springer Science+Business Media, LLC (outside the USA).

引用

页码：208 / 215

页数：7

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