Inflammation, insulin resistance, and obesity

被引：103

作者：

Ferroni P. ^{[1
]}

Basili S. ^{[1
]}

Falco A. ^{[1
]}

Davì G. ^{[1
]}

机构：

[1] Center of Excellence on Aging, 66013 Chieti, Via colle dell'Ara

来源：

Current Atherosclerosis Reports | 2004年 / 6卷 / 6期

关键词：

Obesity; Insulin Resistance; Metabolic Syndrome; Visceral Obesity; Insulin Resistance Syndrome;

D O I：

10.1007/s11883-004-0082-x

中图分类号：

学科分类号：

摘要：

Obesity, in particular visceral obesity, has strong associations with cardiovascular disease and is related to many factors that are constituents of the metabolic syndrome. Increasing evidence suggests that features of the metabolic syndrome, including visceral obesity, are associated with a low-grade inflammatory state. Indeed, visceral fat is a source of several molecules, such as leptin, adiponectin, tumor necrosis factor-α, and interleukin 6, that are collectively called adipokines. All of them may induce a proinflammatory state and oxidative damage, leading to initiation and progression of atherosclerosis. Reduced-energy diets might represent an effective and healthful approach for long-term weight loss in patients with metabolic syndrome by reducing the underlying inflammatory condition. Copyright © 2004 by Current Science Inc.

引用

页码：424 / 431

页数：7

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