Comparative analysis of esterase and paraoxonase activities of different serum albumin species

被引：0
作者：
N. V. Goncharov
M. A. Terpilovskii
V. I. Shmurak
D. A. Belinskaya
P. V. Avdonin
机构：
[1] Russian Academy of Sciences,Sechenov Institute of Evolutionary Physiology and Biochemistry
[2] Occupational Pathology and Human Ecology,Research Institute of Hygiene
[3] Russian Academy of Sciences,Koltsov Institute of Developmental Biology
来源：
Journal of Evolutionary Biochemistry and Physiology | 2017年 / 53卷
关键词：
albumin; -nitrophenylacetate; paraoxon; esterase activity of albumin; comparative biochemistry;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Enzymatic activities of three types of serum albumin—rat, bovine and human—were analyzed comparatively using a mathematical model. Kinetic and equilibrium constants of carboxylesterase and paraoxonase activities of albumin in Sudlow’s sites I and II were determined. The effects of specific ligands, ibuprofen and warfarin, on enzyme kinetics in these sites were studied. Ibuprofen was found to have an inhibitory effect both on carboxylesterase and paraoxonase albumin activities, whereas warfarin specifically inhibited only carboxylesterase albumin activity.
引用
收藏
页码：271 / 281
页数：10
相关论文
共 122 条
[1]  
McWilliam J.A.(1891)Remarks on a new test for albumin and other proteids Brit. Med. J. 1 837-840
[2]  
Atkinson J.F.(1899)A preliminary note on the fractional precipitation of the globulin and albumin of normal horse’s serum and diphtheric antitoxic serum, and the antitoxic strength of the precipitates J. Exp. Med. 4 649-654
[3]  
He X. M.(1992)Atomic structure and chemistry of human serum albumin Nature 358 209-215
[4]  
Carter D.C.(1999)Crystal structure of human serum albumin at 2.5 Å resolution Protein Engin. 12 439-446
[5]  
Sugio S.(2012)Structural and immunologic characterization of bovine, horse, and rabbit serum albumins Mol. Immunol. 52 174-182
[6]  
Kashima A.(2015)On the enzymatic activity of albumin Bioorg. Khim. 41 131-144
[7]  
Mochizuki S.(2015)UniProt: a hub for protein information Nucleic Acids Res. 43 204-212
[8]  
Noda M.(1977)Rat liver pre-proalbumin: complete amino acid sequence of the prepiece. Analysis of the direct translation product of albumin messenger RNA J. Biol. Chem. 252 6846-6855
[9]  
Kobayashi K.(2012)Structures of bovine, equine and leporine serum albumin Acta Crystallogr. D Biol. Crystallogr. 68 1278-1289
[10]  
Majorek K.A.(2005)Structural basis of the drug-binding specificity of human serum albumin J. Mol. Biol. 353 38-52
12345678910