Analysis of Trace Elements in Bronchoalveolar Lavage of Patients with Diffuse Lung Diseases

被引：0
作者：
E. Bargagli
F. Monaci
N. Bianchi
C. Bucci
P. Rottoli
机构：
[1] University of Siena,Respiratory Diseases Section, Department of Clinical Medicine and Immunological Sciences
[2] University of Siena,Department of Environmental Biology
[3] Le Scotte Hospital,Respiratory Diseases Section, Department of Clinical Medicine and Immunological Sciences
来源：
Biological Trace Element Research | 2008年 / 124卷
关键词：
Trace elements; Diffuse lung diseases; Bronchoalveolar lavage; Langerhans cell histiocytosis;
D O I：
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中图分类号：
学科分类号：
摘要：
Airborne trace elements are implicated in the etio-pathogenesis of a large number of pulmonary diseases. The aim of this study was to evaluate the reliability and effectiveness of direct determination of Cd, Cr, Cu, Fe, Mn, Ni, Pb, V, and Zn concentrations in bronchoalveolar lavage (BAL) samples from patients with sarcoidosis, idiopathic pulmonary fibrosis, and Langerhans cell histiocytosis and healthy (smoking and non-smoking) controls. A total of 44 individuals were recruited among sarcoidosis, idiopathic pulmonary fibrosis, and Langerhans cell histiocytosis patients and healthy (smoking and non-smoking) controls. Average Mn concentrations in BAL from patients were 45% lower than in controls (p < 0.01) and remarkable decreases in average concentrations of Cr, Ni and Zn were also found in BAL from patients with idiopathic pulmonary fibrosis and Langerhans cell histiocytosis. As these diseases are characterized by the enhanced activation of certain immunomodulatory cells and by generation of free radicals, the depressed Mn, Zn, Cr and Ni concentrations in BAL from patients may be due to oxidative stress. These preliminary results indicate that assessment of the elemental composition of BAL is a promising approach to study the pathogenesis of diffuse lung diseases and Langerhans cell histiocytosis.
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页码：225 / 235
页数：10
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