Systemic concentrations of asymmetric dimethylarginine (ADMA) in chronic obstructive pulmonary disease (COPD): state of the art

被引：0
作者：
Angelo Zinellu
Alessandro G. Fois
Arduino A. Mangoni
Panagiotis Paliogiannis
Elisabetta Sotgiu
Elisabetta Zinellu
Viviana Marras
Pietro Pirina
Ciriaco Carru
机构：
[1] University of Sassari,Department of Biomedical Sciences
[2] University of Sassari,Department of Clinical and Experimental Medicine
[3] Azienda Ospedaliero Universitaria (AOU),Department of Respiratory Diseases
[4] Flinders University,Department of Clinical Pharmacology, College of Medicine and Public Health
来源：
Amino Acids | 2018年 / 50卷
关键词：
ADMA; Arginine; Chronic obstructive pulmonary disease; Inflammation; Oxidative stress;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Experimental evidence suggests that oxidative stress (OS) may increase the activity of arginine methylating enzymes that produce the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA). In addition, it is well documented that OS can significantly decrease the synthesis and/or activity of ADMA degrading enzymes, thus causing ADMA accumulation in biological fluids. Recent reports have focused on circulating methylated arginine concentrations in chronic obstructive pulmonary disease, a disease characterized by a significant increase in OS. This review discusses the results of these studies and the opportunities for further research in this area.
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页码：1169 / 1176
页数：7
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