The emerging role of apolipoprotein C-III: beyond effects on triglyceride metabolism

被引：0
作者：
Mengdie Luo
Daoquan Peng
机构：
[1] The Second Xiangya Hospital,Department of Cardiovascular Medicine
[2] Central South University,undefined
来源：
Lipids in Health and Disease | / 15卷
关键词：
Apolipoproteins; Atherosclerosis; Gene therapy;
D O I：
暂无
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学科分类号：
摘要：
Apolipoprotein C-III has been referred to as an important participant in the metabolism of triglyceride-rich lipoproteins, leading to hypertriglyceridemia and thereafter cardiovascular disease. Accumulating evidence indicates that apolipoprotein C-III is a multifaceted protein which not only regulates triglyceride metabolism, but also participates in the atherosclerotic lesion formation and several other pathological processes involved in atherosclerosis. Based on data from experiments and clinical trials, some novel therapies such as antisense technology emerge.
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[11]  
Peloso GM(2016)D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile Nat Commun 7 10353-1705
[12]  
Auer PL(2008)A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection Science 322 1702-1771
[13]  
Jørgensen AB(2014)Mechanisms That Regulate Macrophage Burden in Atherosclerosis Circ Res 114 1757-225
[14]  
Frikke-Schmidt R(2007)Apolipoprotein CIII-Induced THP-1 Cell Adhesion to Endothelial Cells Involves Pertussis Toxin-Sensitive G Protein- and Protein Kinase C-Mediated Nuclear Factor- κB Activation Arterioscler Thromb Vasc Biol 27 219-687
[15]  
Nordestgaard BG(2006)Apolipoprotein CIII induces expression of vascular cell adhesion molecule-1 in vascular endothelial cells and increases adhesion of monocytic cells Circulation 114 681-624
[16]  
Ooi EMM(2013)Statins suppress apolipoprotein CIII-induced vascular endothelial cell activation and monocyte adhesion Eur Heart J 34 615-589
[17]  
Barrett PHR(2015)Aggravated restenosis and atherogenesis in ApoCIII transgenic mice but lack of protection in ApoCIII knockouts: the effect of authentic triglyceride-rich lipoproteins with and without ApoCIII Cardiovasc Res 107 579-1760
[18]  
Chan DC(2011)The hemostatic system as a modulator of atherosclerosis N Engl J Med 364 1746-471
[19]  
Sundaram M(2010)Apolipoprotein C-III predicts cardiovascular mortality in severe coronary artery disease and is associated with an enhanced plasma thrombin generation J Thromb Haemost 8 463-1267
[20]  
Zhong S(2013)Factor II activity is similarly increased in patients with elevated apolipoprotein CIII and in carriers of the factor II 20210A allele J Am Heart Assoc 2 e000440-2177
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