Click polymerization for the synthesis of reduction-responsive polymeric prodrug

被引：0
作者：
Xiaojin Zhang
Hongquan Wang
Yu Dai
机构：
[1] China University of Geosciences,Engineering Research Center of Nano
来源：
Journal of Nanoparticle Research | 2018年 / 20卷
关键词：
Reduction-responsive; Click polymerization; Methotrexate; Polymeric prodrug; Micelles; Drug delivery applications;
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摘要：
Click polymerization is a powerful polymerization technique for the construction of new macromolecules with well-defined structures and multifaceted functionalities. Here, we synthesize reduction-responsive polymeric prodrug PEG-b-(PSS-g-MTX)-b-PEG containing disulfide bonds and pendant methotrexate (MTX) via two-step click polymerization followed by conjugating MTX to pendant hydroxyl. MTX content in polymeric prodrug is 13.5%. Polymeric prodrug is able to form polymeric micelles by self-assembly in aqueous solution. Polymeric micelles are spherical nanoparticles with tens of nanometers in size. Of note, polymeric micelles are reduction-responsive due to disulfide bonds in the backbone of PEG-b-(PSS-g-MTX)-b-PEG and could release pendant drugs in the presence of the reducing agents such as dl-dithiothreitol (DTT).
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