Femtosecond laser-assisted selective reduction of neovascularization in rat cornea

被引:0
作者
Mehra S. Sidhu
Min-Yeong Choi
Suk-Yi Woo
Hyun-Kyu Lee
Heung-Soon Lee
Kyu-Jin Kim
Sae Chae Jeoung
Jun-Sub Choi
Choun-Ki Joo
Il-Hong Park
机构
[1] Korea Research Institute of Standards and Science,Center for Medical Metrology, Division of Convergence Technology
[2] University of Science and Technology,Department of Medical Physics
[3] The Catholic University of Korea and The Catholic Institute for Visual Science,Department of Ophthalmology and Visual Sciences, Seoul St. Mary’s Hospital
[4] HanbitNanoBioTech. Co.,undefined
[5] Ltd.,undefined
来源
Lasers in Medical Science | 2014年 / 29卷
关键词
Rat; Cornea; Corneal neovascularization; Femtosecond laser; Microsurgery;
D O I
暂无
中图分类号
学科分类号
摘要
Nonlinear multiphoton absorption induced by focusing near infrared (NIR) femtosecond (fs) laser pulses into a transparent cornea allows surgery on neovascular structures with minimal collateral damage. In this report, we introduce an fs laser-based microsurgery for selective treatment of rat corneal neovascularizations (in vivo). Contiguous tissue effects are achieved by scanning a focused laser pulse below the corneal surface with a fluence range of 2.2–8.6 J/cm2. The minimal visible laser lesion (MVL) threshold determined over the corneal neovascular structures was found to be 4.3 J/cm2. Histological and optical coherence tomography examinations of the anterior segment after laser irradiations show localized degeneration of neovascular structures without any unexpected change in adjacent tissues. Furthermore, an approximately 30 % reduction in corneal neovascularizations was observed after 5 days of fs laser exposure. The femtosecond laser is thus a promising tool for minimally invasive intrastromal surgery with the aid of a significantly smaller and more deterministic photodisruptive energy threshold for the interaction between the fs laser pulse and corneal neovascular structures.
引用
收藏
页码:1417 / 1427
页数:10
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