Synthesis of antineoplaston A10 analogs as potential antitumor agents

被引：0
|
作者：
Bo-Gil Choi
Ok-Young Kim
Byung-Ho Chung
Won-Jea Cho
Seung-Hoon Cheon
Sang-Un Choi
Chong-Ock Lee
机构：
[1] Chonnam National University,College of Pharmacy
[2] Korea Research Institute of Chemical Technology,undefined
来源：
Archives of Pharmacal Research | 1998年 / 21卷
关键词：
Antineoplaston A10; Aniline mustards; Piperidinedione derivatives; Antitumor agent;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Several aniline mustard analogues were obtained by introducingN,N-bis(2-chloroethyl)amino moiety to phenyl ring of A10 analogues in order to increase reactivity of A10 analogs and selectivity into DNA. Thein vitro antitumor activity of synthesized compounds was evaluated using five different solid tumor cell lines by SRB method. Aniline mustard analogues exhibited more potent antitumor activity than A10 analogs. Especially,m-aniline mustard of benzoyl analogue displayed remarkable antitumor activity.
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页码：157 / 163
页数：6
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