Bioequivalence of Rebamipide Granules and Tablets in Healthy Adult Male Volunteers

被引：0
|
作者：
Setsuo Hasegawa
Hisakuni Sekino
Osamu Matsuoka
Kazunori Saito
Hisayuki Sekino
Aki Morikawa
Kaya Uchida
Masami Koike
Junichi Azuma
机构：
[1] Sekino Clinical Pharmacology Clinic,Nishiwaki Laboratory, Bioassay Division
[2] Japan Clinical Laboratories,Department of Bioavailability Research, Formulation Research Institute, Therapeutic Application Development Group, Pharmaceutical Product Group, Pharmaceutical Marketing Division, Tokyo Branch
[3] Inc.,Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Sciences
[4] Otsuka Pharmaceutical Co.,undefined
[5] Ltd,undefined
[6] Osaka University,undefined
来源：
Clinical Drug Investigation | 2003年 / 23卷
关键词：
Gastritis; Gastric Ulcer; Multiple Reaction Monitoring; Granule Formulation; Bioequivalence Study;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Objective: Rebamipide tablets, which are used in the treatment of patients with gastric ulcers or gastritis, can be difficult to administer in subjects with reduced swallowing ability or impaired swallowing. The granule formulation may be more easily administered in these patients. The bioequivalence between rebamipide granules (20%/0.5g) and tablets (100mg) was determined in healthy male adult volunteers, in accordance with the Partially Revised Guidelines for Bioequivalence Studies of Generic Products.
引用
收藏
页码：771 / 779
页数：8
相关论文
共 50 条
  • [1] Bioequivalence of rebamipide granules and tablets in healthy adult male volunteers
    Hasegawa, S
    Sekino, H
    Matsuoka, O
    Saito, K
    Sekino, H
    Morikawa, A
    Uchida, K
    Koike, M
    Azuma, J
    CLINICAL DRUG INVESTIGATION, 2003, 23 (12) : 771 - 779
  • [2] Pharmacokinetics and bioequivalence of sildenafil granules and sildenafil tablets in Korean healthy volunteers
    Zheng, Renhua
    Kim, Bo-Hyung
    INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2014, 52 (06) : 530 - 536
  • [3] Average bioequivalence study of clarithromycin tablets in healthy male volunteers
    Lohitnavy, M
    Lohitnavy, O
    Sareekan, K
    Chaiyaput, W
    JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2003, 28 (03) : 187 - 190
  • [4] Average bioequivalence of generic clarithromycin tablets in healthy Thai male volunteers
    Lohitnavy, O
    Lohitnavy, M
    Sareekan, K
    Polnok, S
    Taytiwat, P
    BIOPHARMACEUTICS & DRUG DISPOSITION, 2003, 24 (06) : 229 - 231
  • [5] Bioequivalence of two oral formulations of clopidogrel tablets in healthy male volunteers
    El Ahmady, O.
    Ibrahim, M.
    Hussein, A. M.
    Bustami, R. T.
    INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2009, 47 (12) : 780 - 784
  • [6] Pharmacokinetic and bioequivalence studies of generic clarithromycin tablets in healthy male volunteers
    Lohitnavy, M
    Lohitnavy, O
    Chaijittiprasert, K
    Taytiwat, P
    Polnok, S
    Sareekan, K
    PHARMAZIE, 2003, 58 (01): : 72 - 73
  • [7] Pharmacokinetics and Bioequivalence Evaluation of 2 Loxoprofen Tablets in Healthy Egyptian Male Volunteers
    Helmy, Sally A.
    CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2013, 2 (02): : 173 - 177
  • [8] Pharmacokinetic and bioequivalence study of two brands of valsartan tablets in healthy male volunteers
    Zakeri-Milani, Parvin
    Valizadeh, Hadi
    Islambulchilar, Ziba
    Nemati, Mahboob
    ARZNEIMITTELFORSCHUNG-DRUG RESEARCH, 2010, 60 (02): : 76 - 80
  • [9] Bioavailability and bioequivalence of Risdiplam tablets in healthy volunteers
    Kletzl, H.
    Heinig, K.
    Jaber, B.
    Lomeli, B.
    Yeung, W.
    Young, A.
    Coleman, H.
    Morrison, D.
    NEUROMUSCULAR DISORDERS, 2023, 33 : S93 - S93
  • [10] Bioequivalence Study of 100-mg Cilostazol Tablets in Healthy Thai Adult Volunteers
    Chatsiricharoenkul, Somruedee
    Nanchaipruek, Yanisorn
    Manopinives, Patcharaporn
    Atakulreka, Suparat
    Niyomnaitham, Suvimol
    CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL, 2019, 91 : 11 - 16
12345