A Model of Ocular Dominance Column Development by Competition for Trophic Factor: Effects of Excess Trophic Factor with Monocular Deprivation and Effects of Antagonist of Trophic Factor

被引：0
|
作者：
Anthony E. Harris
G. Bard Ermentrout
Steven L. Small
机构：
[1] University of Pittsburgh,Intelligent Systems Program, Center for the Neural Basis of Cognition, Department of Neurosurgery
[2] University of Pittsburgh,Center for the Neural Basis of Cognition, Department of Mathematics and Statistics
[3] University of Maryland Medical School,Department of Neurology
来源：
Journal of Computational Neuroscience | 2000年 / 8卷
关键词：
ocular dominance; critical period; mathematical model; neurotrophin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Recent experimental evidence has implicated neurotrophic factors (NTs) in the competitive process believed to drive the development of ocular dominance (OD) columns. Application of excess amounts of particular NTs can prevent the segregation process, suggesting that they could be the substance for which geniculocortical afferents compete during development. We have previously presented a model that accounts for normal OD development as well as the prevention of that development with excess NT. The model uses a Hebbian learning rule in combination with competition for a limiting supply of cortical trophic factor to drive OD segregation, without any weight normalization procedures.
引用
收藏
页码：227 / 250
页数：23
相关论文
共 50 条
12345