Inhibition of Akt activity induces the mesenchymal-to-epithelial reverting transition with restoring E-cadherin expression in KB and KOSCC-25B oral squamous cell carcinoma cells

被引:0
作者
Kyoung-Ok Hong
Ji-Hong Kim
Ji-Soo Hong
Hye-Jung Yoon
Jae-Il Lee
Sam-Pyo Hong
Seong-Doo Hong
机构
[1] Seoul National University,Department of Oral Pathology, School of Dentistry and Dental Research Institute
来源
Journal of Experimental & Clinical Cancer Research | / 28卷
关键词
Oral Cancer; Oral Squamous Cell Carcinoma; Oral Squamous Cell Carcinoma; Oral Squamous Cell Carcinoma Cell; Twist Expression;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 212 条
[1]  
Birchmeier C(1996)Epithelial-mesenchymal transitions in cancer progression Acta Anat 156 217-226
[2]  
Birchmeier W(2003)The LIM-only protein, LMO4, and the LIM domain-binding protein, LDB1, expression in squamous cell carcinomas of the oral cavity Br J Cancer 88 1543-1548
[3]  
Brand-Saberi B(2006)The epithelial-mesenchymal transition: new insights in signaling, development, and disease J Cell Biol 172 973-981
[4]  
Mizunuma H(2006)Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis Cancer Res 66 8319-8326
[5]  
Miyazawa J(2001)AKT plays a central role in tumorigenesis Proc Natl Acad Sci USA 98 10983-10985
[6]  
Sanada K(2001)High expression levels of NFκB, IκBα and Akt kinase in squamous cell carcinoma of the oral cavity Cancer 92 3037-3044
[7]  
Imai K(2001)AKT1/PKBα kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells Am J Pathol 159 431-437
[8]  
Lee JM(2001)Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation Cancer Res 61 3986-3997
[9]  
Dedhar S(2005)ERBB receptors and cancer: the complexity of targeted inhibitors Nat Rev Cancer 5 341-354
[10]  
Kalluri R(1992)Association of phosphorylated insulin-like growth factor-I receptor with the SH2 domains of phosphorylated 3-kinase p85 J Biol Chem 267 11337-11343