Estrogen and Autoimmune Disease

被引：0
作者：
Sara E. Walker
机构：
[1] The University of Missouri,Departments of Internal Medicine and Pathology and Anatomical Sciences
来源：
Clinical Reviews in Allergy & Immunology | 2011年 / 40卷
关键词：
Autoimmunity; Estrogen; Systemic lupus erythematosus; Rheumatoid arthritis; Sjogren’s syndrome; Multiple sclerosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Estrogenic hormones possess both immunostimulating and immunosuppressive properties. In systemic lupus erythematosus (SLE), pregnancy is associated with disease flares. In some situations, exogenous estrogen predisposes to development of new SLE, flares of preexisting SLE, and thromboses in susceptible individuals. In contrast, treatment with exogenous estrogen protects postmenopausal rheumatoid arthritis (RA) patients from active RA and osteoporosis. The search for estrogen-like compounds with anti-inflammatory properties may expand treatment options in RA.
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页码：60 / 65
页数：5
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