Porins and small-molecule translocation across the outer membrane of Gram-negative bacteria

被引：0

作者：

Julia Vergalli

Igor V. Bodrenko

Muriel Masi

Lucile Moynié

Silvia Acosta-Gutiérrez

James H. Naismith

Anne Davin-Regli

Matteo Ceccarelli

Bert van den Berg

Mathias Winterhalter

Jean-Marie Pagès

机构：

[1] UMR-MD1,Department of Physics

[2] U-1261,Division of Structural Biology

[3] Aix-Marseille Université,Department of Life Sciences and Chemistry

[4] INSERM,undefined

[5] SSA,undefined

[6] IRBA,undefined

[7] MCT,undefined

[8] Faculté de Pharmacie,undefined

[9] University of Cagliari,undefined

[10] CNR/IOM,undefined

[11] Cittadella Universitaria di Monserrato,undefined

[12] Institut de Biologie Intégrative de la Cellule (I2BC),undefined

[13] UMR9198,undefined

[14] CNRS,undefined

[15] CEA,undefined

[16] Université Paris Sud,undefined

[17] Université Paris Saclay,undefined

[18] Nuffield Department of Medicine,undefined

[19] Rosalind Franklin Institute,undefined

[20] Rutherford Appleton Laboratory,undefined

[21] Institute for Cell and Molecular Biosciences,undefined

[22] Medical School,undefined

[23] Newcastle University,undefined

[24] Jacobs University Bremen,undefined

来源：

Nature Reviews Microbiology | 2020年 / 18卷

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摘要：

Gram-negative bacteria and their complex cell envelope, which comprises an outer membrane and an inner membrane, are an important and attractive system for studying the translocation of small molecules across biological membranes. In the outer membrane of Enterobacteriaceae, trimeric porins control the cellular uptake of small molecules, including nutrients and antibacterial agents. The relatively slow porin-mediated passive uptake across the outer membrane and active efflux via efflux pumps in the inner membrane creates a permeability barrier. The synergistic action of outer membrane permeability, efflux pump activities and enzymatic degradation efficiently reduces the intracellular concentrations of small molecules and contributes to the emergence of antibiotic resistance. In this Review, we discuss recent advances in our understanding of the molecular and functional roles of general porins in small-molecule translocation in Enterobacteriaceae and consider the crucial contribution of porins in antibiotic resistance.

引用

页码：164 / 176

页数：12