Antidepressant-like effect of guanosine involves activation of AMPA receptor and BDNF/TrkB signaling

[1] Otte C(2016)Major depressive disorder Nat Rev Dis Primers 2 16065-151

[2] Gold SM(2006)New approaches to antidepressant drug discovery: beyond monoamines Nat Rev Neurosci 7 137-931

[3] Penninx BW(2011)The hippocampus, neurotrophic factors and depression: possible implications for the pharmacotherapy of depression CNS Drugs 25 913-659

[4] Pariante CM(2003)Diagnosis and definition of treatment-resistant depression Biol Psychiatry 53 649-1150

[5] Etkin A(2015)Towards new mechanisms: an update on therapeutics for treatment-resistant major depressive disorder Mol Psychiatry 20 1142-27

[6] Fava M(2014)Pathophysiology of depression and innovative treatments: remodeling glutamatergic synaptic connections Dialogues Clin Neurosci 16 11-813

[7] Mohr DC(2000)Effects of the potent ampakine CX614 on hippocampal and recombinant AMPA receptors: interactions with cyclothiazide and GYKI 52466 Mol Pharmacol 58 802-64

[8] Schatzberg AF(2004)Neurotrophic effects of antidepressant drugs Curr Opin Pharmacol 4 58-815

[9] Berton O(2003)Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects Arch Gen Psychiatry 60 804-646

[10] Nestler EJ(2011)Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression Mol Psychiatry 16 634-8697

[1] Otte C(2016)Major depressive disorder Nat Rev Dis Primers 2 16065-151

[2] Gold SM(2006)New approaches to antidepressant drug discovery: beyond monoamines Nat Rev Neurosci 7 137-931

[3] Penninx BW(2011)The hippocampus, neurotrophic factors and depression: possible implications for the pharmacotherapy of depression CNS Drugs 25 913-659

[4] Pariante CM(2003)Diagnosis and definition of treatment-resistant depression Biol Psychiatry 53 649-1150

[5] Etkin A(2015)Towards new mechanisms: an update on therapeutics for treatment-resistant major depressive disorder Mol Psychiatry 20 1142-27

[6] Fava M(2014)Pathophysiology of depression and innovative treatments: remodeling glutamatergic synaptic connections Dialogues Clin Neurosci 16 11-813

[7] Mohr DC(2000)Effects of the potent ampakine CX614 on hippocampal and recombinant AMPA receptors: interactions with cyclothiazide and GYKI 52466 Mol Pharmacol 58 802-64

[8] Schatzberg AF(2004)Neurotrophic effects of antidepressant drugs Curr Opin Pharmacol 4 58-815

[9] Berton O(2003)Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects Arch Gen Psychiatry 60 804-646

[10] Nestler EJ(2011)Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression Mol Psychiatry 16 634-8697