Volume and market share of anti-epileptic drugs in the Netherlands: impact of new drugs

被引：0
作者：
Pieter Knoester
Charles Deckers
Ronald van der Vaart
Bert Leufkens
Yechiel Hekster
机构：
[1] University Medical Centre Nijmegen,Department of Clinical Pharmacy
[2] Dutch Epilepsy Clinics Foundation,Dutch Drug Information Project
[3] Health Care Insurance Board,Department of Pharmacoepidemiology and Pharmacotherapy
[4] Utrecht Institute for Pharmaceutical Sciences (UIPS),undefined
来源：
Pharmacy World and Science | 2005年 / 27卷
关键词：
Antiepileptic drugs; ATC-DDD system; Drug utilisation; Pharmacoepidemiology; Pharmacoeconomics; The Netherlands;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Objective: In the past decade, several new anti-epileptic drugs (AEDs) were introduced in the Netherlands. These new drugs, one of which is lamotrigine, are 6 to 10 times more expensive than conventional anti-convulsants. In 1997, the high cost of lamotrigine, together with a lack of clinical data supporting its superiority over conventional drugs, prompted the Dutch Health Insurance Board to release a guideline in which the use of lamotrigine was restricted to difficult-to-treat patients. Other new drugs that were marketed after 1997 also became subject to this guideline. The utilisation of new AEDs and the cost consequences are the subject of this paper.
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页码：129 / 134
页数：5
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