Update on the diagnosis and treatment of autoimmune pancreatitis

被引:17
作者
Ghazale A.H. [1 ]
Chari S.T. [1 ]
Vege S.S. [1 ]
机构
[1] Miles and Shirley Fiterman Center for Digestive Diseases, Mayo Clinic, Rochester, MN 55905
关键词
Pancreatitis; Pancreatic Cancer; Chronic Pancreatitis; Biliary Stricture; Autoimmune Pancreatitis;
D O I
10.1007/s11894-008-0031-x
中图分类号
学科分类号
摘要
Autoimmune pancreatitis (AIP) is the pancreatic manifestation of a systemic fibroinflammatory disease (IgG4-related systemic disease) in which affected organs demonstrate dense lymphoplasmacytic infiltration with abundant IgG4-positive cells. The diagnosis of AIP and its differentiation from pancreatic cancer, its main differential diagnosis, remains a clinical challenge. The five cardinal features of AIP are characteristic histology, imaging, and serology; other organ involvement; and response to steroid therapy. Recent advances in our understanding of these features have resulted in enhanced recognition and diagnosis of this benign disease. This in turn has resulted in the avoidance of unnecessary surgical procedures for suspected malignancy. This article reviews recent updates in the diagnosis and treatment of autoimmune pancreatitis. © Springer Science+Business Media, LLC 2008.
引用
收藏
页码:115 / 121
页数:6
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[41]  
Yoneda K., Murata K., Katayama K., Et al., Tubulointerstitial nephritis associated with IgG4-related autoimmune disease, Am J Kidney Dis, 50, pp. 455-462, (2007)
[42]  
Pearson R.K., Longnecker D.S., Chari S.T., Et al., Controversies in clinical pancreatology: Autoimmune pancreatitis: Does it exist?, Pancreas, 27, pp. 1-13, (2003)
[43]  
Kamisawa T., Egawa N., Nakajima H., Et al., Morphological changes after steroid therapy in autoimmune pancreatitis, Scand J Gastroenterol, 39, pp. 1154-1158, (2004)
[44]  
Kamisawa T., Okamoto A., Prognosis of autoimmune pancreatitis, J Gastroenterol, 42, SUPPL. 18, pp. 59-62, (2007)
[45]  
Wakabayashi T., Kawaura Y., Satomura Y., Et al., Long-term prognosis of duct-narrowing chronic pancreatitis: Strategy for steroid treatment, Pancreas, 30, pp. 31-39, (2005)
[46]  
Zamboni G., Luttges J., Capelli P., Et al., Histopathological features of diagnostic and clinical relevance in autoimmune pancreatitis: A study on 53 resection specimens and 9 biopsy specimens, Virchows Arch, 445, pp. 552-563, (2004)
[47]  
Ghazale A., Chari S.T., Optimising corticosteroid treatment for autoimmune pancreatitis, Gut, 56, pp. 1650-1652, (2007)
[48]  
Kamisawa T., Yoshiike M., Egawa N., Et al., Treating patients with autoimmune pancreatitis: Results from a long-term follow-up study, Pancreatology, 5, pp. 234-238, (2005)
[49]  
Hirano K., Tada M., Isayama H., Et al., Long-term prognosis of autoimmune pancreatitis without and with corticosteroid treatment, Gut, 56, pp. 1719-1724, (2007)
[50]  
Ghazale A., Chari S., Zhang L., Et al., IgG4-associated cholangitis: Clinical profile and response to therapy, Gastroenterology, (2008)