Synthesis and antidepressant activity of di substituted-5-aryl-1,2,4-triazoles

被引：0
|
作者：
C. Radhika
A. Venkatesham
Manda Sarangapani
机构：
[1] RBVRR Women’s College of Pharmacy,University College of Pharmaceutical Sciences
[2] Kakatiya University,undefined
来源：
Medicinal Chemistry Research | 2012年 / 21卷
关键词：
1,2,4-Triazole; Thiol; Antidepressant activity; Aroyl thiosemicarbazide;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of 5-aryl-1H-1,2,4-triazole-3-thiol (3) were synthesized. Alkylation of thiol group with N,N-dimethyl/diethyl/dicyclo hexyl-(2-chloro ethyl) amine gave compounds N,N-disubstituted-2-(5-aryl-1H-1,2,4-triazol-3-ylthio)ethanamine (4). These compounds were characterized on the basis of IR, 1H NMR, Mass spectral data, and elemental analysis. The newly synthesized compounds were screened for their antidepressant activity by using tail suspension test in mice.
引用
收藏
页码：3509 / 3513
页数：4
相关论文
共 50 条
  • [41] INHIBITIVE ACTION OF SUBSTITUTED 1,2,4-TRIAZOLES
    VOLOSHIN, VF
    GOLOSOVA, OP
    MAZALEVSKAYA, LA
    PROTECTION OF METALS, 1986, 22 (03): : 386 - 387
  • [42] Synthesis and Anticancer Activity of New Substituted Pyrazoles and Their Derived 1,2,4-Triazoles and Sugar Derivatives
    Flefel, Eman M.
    Tantawy, Waled A.
    El-Sayed, Wael A.
    Sayed, Hayam H.
    Fathy, Nahed M.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2013, 50 (02) : 344 - 350
  • [43] SYNTHESIS AND BIOLOGICAL ACTIVITY OF TRI-SUBSTITUTED 1,2,4-TRIAZOLES BEARING BENZIMIDAZOLE MOIETY
    Jiang, Lin
    Wang, Mei-Yan
    Wan, Fu-Xian
    Qu, Zhi-Qiang
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2015, 190 (10) : 1599 - 1605
  • [44] Amino acids as building blocks for the synthesis of substituted 1,2,4-triazoles
    Bibian, Mathieu
    Martinez, Jean
    Fehrentz, Jean-Alain
    TETRAHEDRON, 2011, 67 (37) : 7042 - 7049
  • [45] 1,2,4-TRIAZOLES .8. SYNTHESIS AND ANTI-MICROBIAL ACTIVITY OF 3-ALKYLTHIO-5-PYRIDYL-1,2,4-TRIAZOLES AND RELATED COMPOUNDS
    KUBOTA, S
    UDA, M
    SATO, K
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1978, 26 (03) : 893 - 897
  • [46] A NEW METHOD FOR THE SYNTHESIS OF SUBSTITUTED 3-AMINO-1,2,4-TRIAZOLES
    Bezbarua, Maitreyee Sarma
    Kataky, J. C. S.
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2014, 23 (04) : 425 - 428
  • [47] Four-Component Synthesis of Fully Substituted 1,2,4-Triazoles
    Staben, Steven T.
    Blaquiere, Nicole
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (02) : 325 - 328
  • [48] SYNTHESIS AND PROPERTIES OF 3-PERFLUOROOXAALKYL-SUBSTITUTED 1,2,4-TRIAZOLES
    VERSHILOV, SV
    POPOVA, LM
    MUNGALOV, VE
    RYABININ, NA
    ZHURNAL ORGANICHESKOI KHIMII, 1994, 30 (08): : 1241 - 1244
  • [49] SYNTHESIS AND ANTIHYPERTENSIVE ACTIVITY OF SOME 3-SUBSTITUTED 4H-1,2,4-TRIAZOLES
    EMILSSON, H
    SELANDER, H
    GAARDER, J
    ACTA PHARMACEUTICA SUECICA, 1987, 24 (03): : 123 - 134
  • [50] SYNTHESIS AND ANTIHYPERTENSIVE ACTIVITY OF SOME 3-SUBSTITUTED 4H-1,2,4-TRIAZOLES
    EMILSSON, H
    SELANDER, H
    ACTA PHARMACEUTICA SUECICA, 1983, 20 (06): : 419 - 432
12345