Roles of sirtuins in asthma

被引：0
作者：
Yahui Liu
Guochao Shi
机构：
[1] Ruijin Hospital,Department of Respiratory and Critical Care Medicine
[2] Shanghai Jiao Tong University School of Medicine,Institute of Respiratory Diseases
[3] Ruijin Hospital,Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases
[4] Shanghai Jiao Tong University School of Medicine,undefined
[5] Ruijin Hospital,undefined
[6] Shanghai Jiao Tong University School of Medicine,undefined
来源：
Respiratory Research | / 23卷
关键词：
Sirtuins; Asthma; SIRT1; Modulators;
D O I：
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学科分类号：
摘要：
Sirtuins are nicotinamide adenine dinucleotide (NAD+)-dependent lysine deacylases and deacetylases that participate in a variety of cellular processes, including transcriptional activity, energy metabolism, DNA damage response, inflammation, apoptosis, autophagy, and oxidative stress. As a result, sirtuins are linked to multiple pathophysiological processes, such as cardiovascular diseases, metabolic diseases, autoimmune diseases, infectious diseases, and respiratory diseases. Asthma is the most common respiratory disease, which is characterized by airway inflammation and airway remodeling. Accumulating evidence has indicated that sirtuins are involved in the pathogenesis of asthma. Furthermore, some studies have suggested that sirtuin modulators are potential agents for the treatment of asthma via alteration of the expression or activity of sirtuins. In this review, we illustrate the role of sirtuins in asthma, discuss related molecular mechanisms, and evaluate the sirtuins-targeted therapy for asthma.
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