Synthesis of novel 4-thiazolidione derivatives as antibacterial agents against drug-resistant Staphylococcus epidermidis

被引：0
作者：
Dan Zhao
Huayong Liu
Likang Zheng
Guozhen He
Di Qu
Shiqing Han
机构：
[1] Nanjing University of Technology,College of Biotechnology and Pharmaceutical Engineering
[2] Institute of Medical Microbiology and Institutes of Biomedical Sciences,Key Laboratory of Medical Molecular Virology of Ministry of Education and Ministry of Public Health
[3] Shanghai Medical School of Fudan University,undefined
来源：
Medicinal Chemistry Research | 2013年 / 22卷
关键词：
4-Thiazolidione; Methicillin-resistant ; Methicillin-resistant ; Antibacterial activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of novel substituted 4-thiazolidione derivatives were designed, synthesized, and evaluated in vitro for their antibacterial activities, in comparison with methicillin and ampicillin. Compounds (7d, 7h–k) exhibit good potency in inhibiting the growth of Staphylococcus epidermidis (MIC: 1.57–3.13 μM). Further antibacterial effects of compounds (7d, 7h–k) were investigated using clinical isolates (methicillin-resistant Staphylococcus epidermidis and methicillin-resistant Staphylococcus aureus), in comparison with methicillin and levofloxacin. Compound 7k showed the most potent antibacterial activities among the synthesized compounds.
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页码：3743 / 3750
页数：7
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