Liver support systems: Will they ever reach prime time?

被引：12

作者：

Bañares R. ^{[1
]}

Catalina M.-V. ^{[2
]}

Vaquero J. ^{[3
]}

机构：

[1] Liver Unit, Universidad Complutense de Madrid, Hospital General Universitario Gregorio Marañón, Madrid

[2] Liver Unit, Hospital General Universitario Gregorio Marañón, CIBEREHD, Madrid

[3] Hospital General Universitario Gregorio Marañón, IISGM, CIBEREHD, Madrid

来源：

Current Gastroenterology Reports | 2013年 / 15卷 / 3期

关键词：

Acute liver failure; Acute-on-chronic liver failure; Albumin dialysis; Artificial liver support; Bioartificial liver; Liver support systems; Molecular adsorbent recirculating system; Randomized clinical trial;

D O I：

10.1007/s11894-013-0312-x

中图分类号：

学科分类号：

摘要：

Liver support systems aim to provide temporary support of liver function while maintaining extra-hepatic function in patients with liver failure. Important advances have been achieved in the design of artificial and bio-artificial devices, but the current systems are far from meeting the ideal. Artificial devices provide detoxification through different dialysis procedures, whereas bio-artificial devices add synthetic functions by incorporating a cellular component into the system. Overall, liver support systems have consistently shown beneficial effects on the pathophysiology of liver failure, especially in acute-on-chronic liver failure. However, these beneficial effects have not been translated into an improvement of survival. Our review discusses the current evidence, paying special attention to the clinical aspects of (bio)-artificial liver support devices. © 2013 Springer Science+Business Media New York.

引用

共 44 条

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