We prove the positivity of the self-diffusion matrix of interacting Brownian particles with hard core when the dimension of the space is greater than or equal to 2. Here the self-diffusion matrix is a coefficient matrix of the diffusive limit of a tagged particle. We will do this for all activities, z>0, of Gibbs measures; in particular, for large z– the case of high density particles. A typical example of such a particle system is an infinite amount of hard core Brownian balls.