Structure-guided simulations illuminate the mechanism of ATP transport through VDAC1

被引：0

作者：

Om P Choudhary

Aviv Paz

Joshua L Adelman

Jacques-Philippe Colletier

Jeff Abramson

Michael Grabe

机构：

[1] Joint Carnegie Mellon University–University of Pittsburgh PhD Program in Computational Biology,Department of Physiology

[2] David Geffen School of Medicine,Department of Biological Sciences

[3] University of California,Department of Pharmaceutical Chemistry

[4] Los Angeles,undefined

[5] University of Pittsburgh,undefined

[6] Université Grenoble Alpes,undefined

[7] Institut de Biologie Structurale,undefined

[8] Centre National de la Recherche Scientifique,undefined

[9] Institut de Biologie Structurale,undefined

[10] Commissariat à l'Énergie Atomique et aux Énergies Alternatives,undefined

[11] Direction des Sciences du Vivant,undefined

[12] Institut de Biologie Structurale,undefined

[13] Institute for Stem Cell Biology and Regenerative Medicine,undefined

[14] National Centre for Biological Sciences–Tata Institute of Fundamental Research,undefined

[15] Cardiovascular Research Institute,undefined

[16] University of California,undefined

[17] San Francisco,undefined

来源：

Nature Structural & Molecular Biology | 2014年 / 21卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

VDAC channels permeate metabolites from the mitochondrial intermembrane space to the cytosol. Markov state modeling, an approach used in protein-folding simulations, is now applied to examine ATP-permeation rates and pathways through mouse VDAC1.

引用

页码：626 / 632

页数：6

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