Multicentric Castleman's disease in human immunodeficiency virus infection: Two case reports

被引：4
作者：
Caroline Ribeiro Sales A. [1 ]
De Souza Junior V.R. [1 ,2 ,3 ]
Iglis De Oliveira M. [1 ]
Azevedo Braga Albuquerque C. [1 ]
De Barros Campelo Júnior E. [1 ]
Sérgio Ramos De Araújo P. [1 ]
机构：
[1] Federal University of Pernambuco, Av. Prof. Moraes Rego 1235, Recife
[2] University of Glasgow, University Avenue, Glasgow
[3] Universidade Federal de Pernambuco, Rua Capitão Aurélio de Araújo 325, Recife, Pernambuco
来源：
Journal of Medical Case Reports | / 12卷 / 1期
关键词：
Castleman's disease; HHV-8; HIV; Lymph nodes enlargement;
D O I：
10.1186/s13256-018-1656-5
中图分类号：
学科分类号：
摘要：
Background: Castleman's Disease is a rare B-cell lymphoproliferative disease. It is mostly benign and is characterized by non-neoplastic lymph node hypertrophy, associated with infection by human herpesvirus-8 in people with the human immunodeficiency virus/acquired immunodeficiency syndrome. Although the unicentric or localized form presents as benign, the multifocal form can manifest severe systemic symptoms. We report two unusual cases of men presenting cervical enlarged lymph nodes that were believed to be infectious. Case presentation: The first case is a 41-year-old feoderm man who presented to the Department of Infectious Diseases of the Hospital das Clínicas in May 2015, with irregular fever history (38-39 °C), dyspnea, weight loss (8 kg/1 year), and asthenia with increased cervical lymph nodes of 1-year duration. His immunohistochemical diagnosis presented Castleman's disease in plasmacytic/diffuse form. In the second case, a 35-year-old feoderm man presented at the same hospital with multiple cervical enlarged lymph nodes and histopathological evidence of Castleman's disease associated with human herpesvirus-8. Conclusion: Considering the importance of differential diagnosis of lymphoid disorders, Castleman's disease is a challenging diagnosis in people living with human immunodeficiency virus/acquired immunodeficiency syndrome and can be easily misdiagnosed when lymphoid disorders are present in the human immunodeficiency virus/acquired immunodeficiency syndrome population due to nonspecific symptoms and signs. © 2018 The Author(s).
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